 |
| DATE | OPPONENT | SCORE | LINE | OU | RECAP |
| 04/05/2010 | vs Toronto | W 5 - 4 | (-150) | P (9) | Recap |
| 04/07/2010 | vs Toronto | L 7 - 4 | (-175) | O (9) | Recap |
| 04/08/2010 | vs Toronto | L 3 - 1 | (-155) | U (9) | Recap |
| 04/09/2010 | vs Seattle | W 6 - 2 | (-140) | U (9) | Recap |
| 04/10/2010 | vs Seattle | L 4 - 3 | (120) | U (8½) | Recap |
| 04/11/2010 | vs Seattle | W 9 - 2 | (-165) | O (9) | Recap |
| 04/12/2010 | at Cleveland | W 4 - 2 | (-135) | U (8) | Recap |
| 04/14/2010 | at Cleveland | W 6 - 2 | (110) | U (8½) | Recap |
| 04/15/2010 | at Cleveland | L 3 - 2 | (-115) | U (8½) | Recap |
| 04/16/2010 | at NY Yankees | L 5 - 1 | (195) | U (8½) | Recap |
| 04/17/2010 | at NY Yankees | L 7 - 3 | (150) | O (9½) | Recap |
| 04/18/2010 | at NY Yankees | L 5 - 2 | (150) | U (9) | Recap |
| 04/20/2010 | at Boston | L 7 - 6 | (115) | O (9½) | Recap |
| 04/21/2010 | at Boston | L 8 - 7 | (180) | O (9) | Recap |
| 04/22/2010 | at Boston | W 3 - 0 | (130) | U (9) | Recap |
| 04/23/2010 | vs Detroit | W 5 - 4 | (-120) | P (9) | Recap |
| 04/24/2010 | vs Detroit | L 8 - 4 | (-190) | O (9½) | Recap |
| 04/25/2010 | vs Detroit | W 8 - 4 | (-150) | O (9½) | Recap |
| 04/26/2010 | vs Detroit | L 8 - 6 | (-135) | O (10) | Recap |
| 04/27/2010 | vs Chi White Sox | W 4 - 2 | (-140) | U (9) | Recap |
| 04/28/2010 | vs Chi White Sox | W 6 - 5 | (-120) | O (9) | Recap |
| 04/29/2010 | vs Chi White Sox | L 7 - 5 | (-125) | O (9½) | Recap |
| 04/30/2010 | at Seattle | W 2 - 0 | (110) | U (7) | Recap |
| 05/01/2010 | at Seattle | W 6 - 3 | (185) | O (7) | Recap |
| 05/02/2010 | at Seattle | W 3 - 1 | (105) | U (7½) | Recap |
| 05/03/2010 | at Oakland | W 4 - 2 | (115) | U (8) | Recap |
| 05/04/2010 | at Oakland | L 7 - 6 | (-110) | O (8) | Recap |
| 05/05/2010 | at Oakland | L 4 - 1 | (-135) | U (8½) | Recap |
| 05/06/2010 | vs Kansas City | W 13 - 12 | (-145) | O (9½) | Recap |
| 05/07/2010 | vs Kansas City | W 4 - 1 | (-110) | U (8) | Recap |
| 05/08/2010 | vs Kansas City | W 3 - 2 | (-210) | U (9½) | Recap |
| 05/09/2010 | vs Kansas City | W 6 - 4 | (-165) | O (9½) | Recap |
| 05/11/2010 | vs Oakland | L 7 - 6 | (-180) | O (9) | Recap |
| 05/12/2010 | vs Oakland | W 10 - 1 | (-140) | O (9) | Recap |
| 05/13/2010 | vs Oakland | W 2 - 1 | (-200) | U (8½) | Recap |
| 05/14/2010 | at Toronto | L 16 - 10 | (105) | O (8½) | Recap |
| 05/15/2010 | at Toronto | L 6 - 0 | (120) | U (9) | Recap |
| 05/16/2010 | at Toronto | L 5 - 2 | (-120) | U (8½) | Recap |
| 05/17/2010 | vs LA Angels | W 4 - 3 | (-160) | U (9½) | Recap |
| 05/18/2010 | vs LA Angels | W 8 - 7 | (-130) | O (8½) | Recap |
| 05/19/2010 | vs Baltimore | W 4 - 3 | (-170) | U (9½) | Recap |
| 05/20/2010 | vs Baltimore | W 13 - 7 | (-145) | O (9½) | Recap |
| 05/21/2010 | vs Chi Cubs | W 2 - 1 | (-165) | U (9) | Recap |
| 05/22/2010 | vs Chi Cubs | L 5 - 4 | (-155) | U (9½) | Recap |
| 05/23/2010 | vs Chi Cubs | L 5 - 4 | (-200) | U (9½) | Recap |
| 05/25/2010 | at Kansas City | W 8 - 7 | (-150) | O (9½) | Recap |
| 05/26/2010 | at Kansas City | L 5 - 2 | (-115) | U (9½) | Recap |
| 05/28/2010 | at Minnesota | L 2 - 1 | (105) | U (9) | Recap |
| 05/29/2010 | at Minnesota | L 8 - 3 | (100) | O (8½) | Recap |
| 05/30/2010 | at Minnesota | L 6 - 3 | (110) | O (8½) | Recap |
| 06/01/2010 | at Chi White Sox | W 9 - 6 | (105) | O (8½) | Recap |
| 06/02/2010 | at Chi White Sox | W 9 - 5 | (105) | O (9) | Recap |
| 06/03/2010 | at Chi White Sox | L 4 - 3 | (-120) | U (9) | Recap |
| 06/04/2010 | vs Tampa Bay | W 9 - 6 | (-130) | O (10) | Recap |
| 06/05/2010 | vs Tampa Bay | W 6 - 1 | (120) | U (9½) | Recap |
| 06/06/2010 | vs Tampa Bay | L 9 - 5 | (115) | O (10) | Recap |
| 06/07/2010 | vs Seattle | L 4 - 2 | (100) | U (9) | Recap |
| 06/08/2010 | vs Seattle | W 7 - 1 | (-130) | P (8) | Recap |
| 06/09/2010 | vs Seattle | W 12 - 2 | (-210) | O (9½) | Recap |
| 06/10/2010 | vs Seattle | W 12 - 3 | (-210) | O (10) | Recap |
| 06/11/2010 | at Milwaukee | L 6 - 2 | (-115) | U (9½) | Recap |
| 06/12/2010 | at Milwaukee | W 4 - 3 | (110) | U (10½) | Recap |
| 06/13/2010 | at Milwaukee | W 7 - 2 | (115) | O (8) | Recap |
| 06/15/2010 | at Florida | W 3 - 2 | (140) | U (7) | Recap |
| 06/16/2010 | at Florida | W 6 - 3 | (105) | O (8½) | Recap |
| 06/17/2010 | at Florida | W 6 - 4 | (125) | O (9) | Recap |
| 06/18/2010 | at Houston | W 9 - 3 | (-135) | O (9) | Recap |
| 06/19/2010 | at Houston | W 5 - 1 | (-210) | U (9) | Recap |
| 06/20/2010 | at Houston | W 5 - 4 | (-170) | O (8) | Recap |
| 06/22/2010 | vs Pittsburgh | W 6 - 3 | (-250) | U (10½) | Recap |
| 06/23/2010 | vs Pittsburgh | W 13 - 3 | (-190) | O (10½) | Recap |
| 06/24/2010 | vs Pittsburgh | W 6 - 5 | (-280) | O (10½) | Recap |
| 06/25/2010 | vs Houston | L 7 - 4 | (-300) | O (9½) | Recap |
| 06/26/2010 | vs Houston | W 7 - 2 | (-300) | U (10½) | Recap |
| 06/27/2010 | vs Houston | W 10 - 1 | (-170) | O (9) | Recap |
| 06/29/2010 | at LA Angels | L 6 - 5 | (100) | O (9) | Recap |
| 06/30/2010 | at LA Angels | W 6 - 4 | (100) | P (10) | Recap |
| 07/01/2010 | at LA Angels | L 2 - 1 | (110) | U (8½) | Recap |
| 07/02/2010 | vs Chi White Sox | L 5 - 3 | (-185) | U (9½) | Recap |
| 07/03/2010 | vs Chi White Sox | W 3 - 1 | (-158) | U (9½) | Recap |
| 07/04/2010 | vs Chi White Sox | L 5 - 3 | (-160) | U (10) | Recap |
| 07/05/2010 | vs Cleveland | L 9 - 3 | (-215) | O (10½) | Recap |
| 07/06/2010 | vs Cleveland | W 12 - 1 | (-230) | O (9½) | Recap |
| 07/07/2010 | vs Cleveland | W 4 - 3 | (-240) | U (9½) | Recap |
| 07/08/2010 | vs Baltimore | L 6 - 4 | (-260) | O (9½) | Recap |
| 07/09/2010 | vs Baltimore | L 7 - 6 | (-200) | O (10) | Recap |
| 07/10/2010 | vs Baltimore | L 6 - 1 | (-400) | U (10½) | Recap |
| 07/11/2010 | vs Baltimore | L 4 - 1 | (-250) | U (10) | Recap |
| 07/15/2010 | at Boston | W 7 - 2 | (110) | U (9½) | Recap |
| 07/16/2010 | at Boston | W 8 - 4 | (-135) | O (9½) | Recap |
| 07/17/2010 | at Boston | L 3 - 2 | (-150) | U (9) | Recap |
| 07/18/2010 | at Boston | W 4 - 2 | (145) | U (8½) | Recap |
| 07/19/2010 | at Detroit | W 8 - 6 | (105) | O (9½) | Recap |
| 07/20/2010 | at Detroit | W 8 - 0 | (-130) | U (9½) | Recap |
| 07/21/2010 | at Detroit | L 4 - 1 | (110) | U (8½) | Recap |
| 07/22/2010 | vs LA Angels | W 3 - 2 | (-175) | U (8) | Recap |
| 07/23/2010 | vs LA Angels | W 1 - 0 | (-200) | U (10) | Recap |
| 07/24/2010 | vs LA Angels | L 6 - 2 | (-120) | U (10) | Recap |
| 07/25/2010 | vs LA Angels | W 6 - 4 | (-240) | P (10) | Recap |
| 07/27/2010 | vs Oakland | W 3 - 1 | (-245) | U (8) | Recap |
| 07/28/2010 | vs Oakland | L 3 - 1 | (-155) | U (8½) | Recap |
| 07/29/2010 | vs Oakland | W 7 - 4 | (-200) | O (8½) | Recap |
| 07/30/2010 | at LA Angels | N/A | | | |
| 07/31/2010 | at LA Angels | N/A | | | |
| 08/01/2010 | at LA Angels | N/A | | | |
| 08/03/2010 | at Seattle | N/A | | | |
| 08/04/2010 | at Seattle | N/A | | | |
| 08/05/2010 | at Seattle | N/A | | | |
| 08/06/2010 | at Oakland | N/A | | | |
| 08/07/2010 | at Oakland | N/A | | | |
| 08/08/2010 | at Oakland | N/A | | | |
| 08/10/2010 | vs NY Yankees | N/A | | | |
| 08/11/2010 | vs NY Yankees | N/A | | | |
| 08/13/2010 | vs Boston | N/A | | | |
| 08/14/2010 | vs Boston | N/A | | | |
| 08/15/2010 | vs Boston | N/A | | | |
| 08/16/2010 | at Tampa Bay | N/A | | | |
| 08/17/2010 | at Tampa Bay | N/A | | | |
| 08/18/2010 | at Tampa Bay | N/A | | | |
| 08/19/2010 | at Baltimore | N/A | | | |
| 08/20/2010 | at Baltimore | N/A | | | |
| 08/21/2010 | at Baltimore | N/A | | | |
| 08/22/2010 | at Baltimore | N/A | | | |
| 08/23/2010 | vs Minnesota | N/A | | | |
| 08/24/2010 | vs Minnesota | N/A | | | |
| 08/25/2010 | vs Minnesota | N/A | | | |
| 08/26/2010 | vs Minnesota | N/A | | | |
| 08/27/2010 | vs Oakland | N/A | | | |
| 08/28/2010 | vs Oakland | N/A | | | |
| 08/29/2010 | vs Oakland | N/A | | | |
| 08/30/2010 | at Kansas City | N/A | | | |
| 08/31/2010 | at Kansas City | N/A | | | |
| 09/01/2010 | at Kansas City | N/A | | | |
| 09/03/2010 | at Minnesota | N/A | | | |
| 09/04/2010 | at Minnesota | N/A | | | |
| 09/05/2010 | at Minnesota | N/A | | | |
| 09/06/2010 | at Toronto | N/A | | | |
| 09/07/2010 | at Toronto | N/A | | | |
| 09/08/2010 | at Toronto | N/A | | | |
| 09/09/2010 | at Toronto | N/A | | | |
| 09/10/2010 | vs NY Yankees | N/A | | | |
| 09/11/2010 | vs NY Yankees | N/A | | | |
| 09/12/2010 | vs NY Yankees | N/A | | | |
| 09/14/2010 | vs Detroit | N/A | | | |
| 09/15/2010 | vs Detroit | N/A | | | |
| 09/17/2010 | at Seattle | N/A | | | |
| 09/18/2010 | at Seattle | N/A | | | |
| 09/19/2010 | at Seattle | N/A | | | |
| 09/20/2010 | at LA Angels | N/A | | | |
| 09/21/2010 | at LA Angels | N/A | | | |
| 09/22/2010 | at LA Angels | N/A | | | |
| 09/23/2010 | at Oakland | N/A | | | |
| 09/24/2010 | at Oakland | N/A | | | |
| 09/25/2010 | at Oakland | N/A | | | |
| 09/26/2010 | at Oakland | N/A | | | |
| 09/27/2010 | vs Seattle | N/A | | | |
| 09/28/2010 | vs Seattle | N/A | | | |
| 09/29/2010 | vs Seattle | N/A | | | |
| 09/30/2010 | vs LA Angels | N/A | | | |
| 10/01/2010 | vs LA Angels | N/A | | | |
| 10/02/2010 | vs LA Angels | N/A | | | |
| 10/03/2010 | vs LA Angels | N/A | | | |
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