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| DATE | OPPONENT | SCORE | ATS | OU | RECAP |
| 11/13/2009 | vs Loyola of Chicago | W 92 - 54 | W (-21½) | O (139) | Recap |
| 11/15/2009 | vs Western Illinois | W 82 - 50 | | | |
| 11/19/2009 | vs Boston University | W 80 - 70 | L (-15) | | Recap |
| 11/20/2009 | vs Mississippi | L 86 - 74 | L (-1½) | O (158½) | Recap |
| 11/22/2009 | at Dayton | W 83 - 75 | W (-1½) | O (141) | Recap |
| 11/28/2009 | vs IUPUI | W 70 - 57 | | | |
| 12/01/2009 | vs Fort Hays St | W 83 - 76 | | | |
| 12/05/2009 | vs Washington State | W 86 - 69 | W (-9½) | O (146) | Recap |
| 12/08/2009 | vs Xavier | W 71 - 56 | W (-6½) | U (147) | Recap |
| 12/12/2009 | at UNLV | W 95 - 80 | W (2) | O (145½) | Recap |
| 12/19/2009 | at Alabama | W 87 - 74 | W (-3½) | O (144½) | Recap |
| 12/21/2009 | vs Arkansas-Pine Blu | W 90 - 76 | | | |
| 12/29/2009 | vs Cleveland State | W 85 - 56 | W (-17) | U (147½) | Recap |
| 01/03/2010 | vs South Dakota | W 91 - 69 | | | |
| 01/09/2010 | at Missouri | L 74 - 68 | L (5) | U (158) | Recap |
| 01/12/2010 | vs Texas A&M | W 88 - 65 | W (-9) | O (145) | Recap |
| 01/16/2010 | at Colorado | W 87 - 81 | W (-5½) | O (153) | Recap |
| 01/18/2010 | vs Texas | W 71 - 62 | W (-1) | U (159½) | Recap |
| 01/23/2010 | vs Oklahoma State | L 73 - 69 | L (-9½) | U (148) | Recap |
| 01/26/2010 | at Baylor | W 76 - 74 | W (1½) | O (147) | Recap |
| 01/30/2010 | vs Kansas | L 81 - 79 | W (4) | O (154½) | Recap |
| 02/02/2010 | at Nebraska | W 76 - 57 | W (-4) | U (135½) | Recap |
| 02/06/2010 | at Iowa State | W 79 - 75 | L (-6½) | O (149) | Recap |
| 02/13/2010 | vs Colorado | W 68 - 51 | W (-15) | U (154) | Recap |
| 02/17/2010 | vs Nebraska | W 91 - 87 | L (-14½) | O (135½) | Recap |
| 02/20/2010 | at Oklahoma | W 83 - 68 | W (-5½) | O (150½) | Recap |
| 02/23/2010 | at Texas Tech | W 83 - 64 | W (-5½) | U (156) | Recap |
| 02/27/2010 | vs Missouri | W 63 - 53 | W (-6) | U (152) | Recap |
| 03/03/2010 | at Kansas | L 82 - 65 | L (8½) | U (150) | Recap |
| 03/06/2010 | vs Iowa State | L 85 - 82 | L (-15) | O (145) | Recap |
| 03/11/2010 | vs Oklahoma State | W 83 - 64 | W (-5) | O (144½) | Recap |
| 03/12/2010 | vs Baylor | W 82 - 75 | W (-2½) | O (145) | Recap |
| 03/13/2010 | at Kansas | L 72 - 64 | L (6) | U (145½) | Recap |
| 03/18/2010 | vs North Texas | W 82 - 62 | W (-15½) | U (148) | Recap |
| 03/20/2010 | vs BYU | W 84 - 72 | W (-4½) | U (157) | Recap |
| 03/25/2010 | vs Xavier | W 101 - 96 | L (-5½) | O (150½) | Recap |
| 03/27/2010 | vs Butler | L 63 - 56 | L (-4) | U (134½) | Recap |
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