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| DATE | OPPONENT | SCORE | ATS | OU | RECAP |
| 11/15/2009 | vs IUPU Fort Wayne | W 75 - 46 | W (-21) | | Recap |
| 11/18/2009 | vs Oakland | W 58 - 42 | | | |
| 11/23/2009 | vs Arizona | W 65 - 61 | L (-6) | U (128) | Recap |
| 11/24/2009 | vs Gonzaga | L 74 - 61 | L (2½) | O (128) | Recap |
| 11/25/2009 | vs Maryland | W 78 - 69 | W (2½) | O (126) | Recap |
| 12/02/2009 | vs Duke | W 73 - 69 | W (4½) | O (133) | Recap |
| 12/05/2009 | vs Grambling State | W 79 - 46 | | | |
| 12/09/2009 | at Wisc-Green Bay | L 88 - 84 | L (-5½) | O (132½) | Recap |
| 12/12/2009 | vs Marquette | W 72 - 63 | W (-5½) | O (132) | Recap |
| 12/16/2009 | vs Cal Poly | W 90 - 42 | W (-24) | U (134) | Recap |
| 12/23/2009 | vs Wisc-Milwaukee | W 68 - 58 | L (-16½) | U (131½) | Recap |
| 12/27/2009 | vs Illinois-Chicago | W 79 - 43 | W (-22) | U (127½) | Recap |
| 12/31/2009 | vs Ohio State | W 65 - 43 | W (-6) | U (129) | Recap |
| 01/03/2010 | at Penn State | W 63 - 46 | W (-5) | U (122) | Recap |
| 01/06/2010 | at Michigan State | L 54 - 47 | L (6) | U (131½) | Recap |
| 01/09/2010 | vs Purdue | W 73 - 66 | W (1½) | O (125½) | Recap |
| 01/13/2010 | at Northwestern | W 60 - 50 | W (-3) | U (123) | Recap |
| 01/16/2010 | at Ohio State | L 60 - 51 | L (5½) | U (124½) | Recap |
| 01/20/2010 | vs Michigan | W 54 - 48 | L (-8) | U (121½) | Recap |
| 01/24/2010 | vs Penn State | W 79 - 71 | L (-12) | O (117) | Recap |
| 01/28/2010 | at Purdue | L 60 - 57 | W (9½) | U (128) | Recap |
| 02/02/2010 | vs Michigan State | W 67 - 49 | W (-2) | U (126½) | Recap |
| 02/06/2010 | at Michigan | W 62 - 44 | W (0) | U (116½) | Recap |
| 02/09/2010 | vs Illinois | L 63 - 56 | L (-9) | U (124½) | Recap |
| 02/13/2010 | vs Indiana | W 83 - 55 | W (-17½) | O (122) | Recap |
| 02/18/2010 | at Minnesota | L 68 - 52 | L (-1) | U (124) | Recap |
| 02/21/2010 | vs Northwestern | W 70 - 63 | L (-12½) | O (123) | Recap |
| 02/25/2010 | at Indiana | W 78 - 46 | W (-12) | U (124½) | Recap |
| 03/03/2010 | vs Iowa | W 67 - 40 | W (-18) | U (119) | Recap |
| 03/07/2010 | at Illinois | W 72 - 57 | W (-3) | O (121) | Recap |
| 03/12/2010 | vs Illinois | L 58 - 54 | L (-8) | U (120) | Recap |
| 03/19/2010 | vs Wofford | W 53 - 49 | L (-10) | U (114½) | Recap |
| 03/21/2010 | vs Cornell | L 87 - 69 | L (-4) | O (126½) | Recap |
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