Chris Osgood made 46 stops Monday to lead the Red Wings over the Avalanche 4-3 at Pepsi Center.
Detroit won as a +105 underdog, while Over-Under bettors who played OVER the total of 5.5 were rewarded at the payout window.
Detroit got goals from Nicklas Lidstrom, Jiri Hudler, Niklas Kronwall, and Johan Franzen in the victory. Hudler opened the scoring at 5:35 of the first period.
Chris Osgood turned in a 46-save effort for the Red Wings.
Matt Duchene (2) and T.J. Galiardi scored for the Avalanche, finding the net behind Chris Osgood.
Peter Budaj stopped 26 of 30 shots for the Avalanche, but it wasn't enough to earn the victory.
On the power play, Detroit went 4-for-6, while the Avalanche were 1-for-7 with the man advantage.
Colorado outshot Detroit 49-30 in the game.
Detroit heads into a battle against the Stars. Colorado, meanwhile, will have their next action against Edmonton.