The Penguins beat Colorado 6-3 on Tuesday, earning a victory backstopped by Marc-Andre Fleury's 24 saves.
Pittsburgh was favored by -170 and came through for bettors backing them. The game went OVER the consensus closing total of 5.5.
Pittsburgh got goals from Pascal Dupuis, Brooks Orpik, Evgeni Malkin, James Neal, Jordan Staal, and Kris Letang in the victory. Staal opened the scoring at 18:33 of the first period.
Marc-Andre Fleury turned in a 24-save effort for the Penguins.
Colorado got goals from Jay McClement, David Jones, and Matt Duchene in the loss, but it wasn't enough.
Semyon Varlamov stopped 27 of 33 shots for the Avalanche, but it wasn't enough to earn the victory.
On the power play, Pittsburgh went 1-for-7, while the Avalanche were 0-for-2 with the man advantage.
Colorado lost the shots on goal battle to Pittsburgh by a margin of 33-27.
Pittsburgh looks to continue their winning ways next game with a battle against the Lightning. The Avalanche will aim to get back on the winning track at Minnesota.