Pittsburgh's defense, led by netminder Marc-Andre Fleury, shut down New York 2-0 at Consol Energy Centre on on Tuesday.
Pittsburgh won as a -122 favorite, while Over-Under bettors who played UNDER the total of 5 were rewarded at the payout window.
Pittsburgh got goals from Steve Sullivan and Evgeni Malkin in the victory. Malkin opened the scoring at 1:05 of the second period.
Marc-Andre Fleury turned in a 27-save effort for the Penguins.
New York got a 29-stop effort from Henrik Lundqvist in the loss.
On the power play, Pittsburgh went 1-for-2, while the Rangers were 0-for-3 with the man advantage.
New York lost the shots on goal battle to Pittsburgh by a margin of 31-27.
Next game, Pittsburgh takes its act home to face Tampa Bay looking for another win. For New York, they head on the road to face New York.