San Jose was shut out 1-0 on Thursday, stoned by Ryan Miller who stopped all 39 shots fired his way.
Buffalo was an underdog by +160 and came through for bettors backing them. The game went UNDER the consensus closing total of 5.5.
Buffalo got a goal from Drew Stafford in the victory. Stafford opened the scoring at 18:51 of the first period.
Ryan Miller turned in a 39-save effort for the Sabres.
Antti Niemi stopped 18 of 19 shots for the Sharks, but it wasn't enough to earn the victory.
On the power play, Buffalo went 0-for-3, while the Sharks were 0-for-2 with the man advantage.
San Jose outshot Buffalo 39-19 in the game.
Buffalo heads into a battle against the Canucks. San Jose, meanwhile, will have their next action against St. Louis.