The Penguins beat New York 4-2 on Friday, earning a victory backstopped by Tomas Vokoun's 33 saves.
Pittsburgh won as a -154 favorite, while Over-Under bettors who played PUSH the total of 6 were rewarded at the payout window.
Pittsburgh got goals from Pascal Dupuis, Chris Kunitz, Brandon Sutter, and Joe Vitale in the victory. Vitale opened the scoring at 8:11 of the second period.
Tomas Vokoun turned in a 33-save effort for the Penguins.
New York got goals from Mark Streit and Josh Bailey in the loss, but it wasn't enough.
Evgeni Nabokov stopped 21 of 24 shots for the Islanders, but it wasn't enough to earn the victory.
On the power play, Pittsburgh went 0-for-2, while the Islanders were 0-for-2 with the man advantage.
Pittsburgh lost the shots on goal battle to New York by a margin of 35-25.
Pittsburgh heads into a battle against the Flyers. New York, meanwhile, will have their next action against Florida.