Matt Cain Giants at Home vs Cleveland Indians in MLB Betting Odds Clash

A key battle on the MLB betting odds menu sees the visiting Cleveland Indians dueling the San Francisco Giants on Wednesday at AT&T Park.

Matt Cain gets the call for the San Francisco Giants and he will try to build on a 3-8 mark. In the other dugout, Carlos Carrasco brings a 10-4 ledger to the game for the Cleveland Indians as he tries to quiet the Giants bats.

Sportsbook Odds & Computer Pick

Those betting on the visitors in this one found the Cleveland Indians listed as favorites of -205 at most sportsbooks, including Sportsbook. Total bettors saw the number open in the area of 8.5, check for odds updates at Sportsbook.

Odds Shark prediction models pick the Giants to win this game 4.2-4.0. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Cleveland Indians vs San Francisco Giants Matchup

Team Betting Records & Power Rankings

The San Francisco Giants sport a record of 36-59 heading into this matchup, while the Cleveland Indians sit at 48-44 on the season Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs Cleveland injuries news.

It's a MLB baseball betting matchup between the No. 23-rated San Francisco Giants and the league No. 8-ranked Cleveland Indians, according to the latest MLB power poll here at Odds Shark.

Statistical Matchup

Rating these teams in several key categories is important for handicappers and San Francisco has baseball's No. 28-rated offensive output, at 8.38 hits per game. The Cleveland Indians average 8.74 hits per game, good for No. 14 on the list.

San Francisco owns the No. 23 defense, allowing 3.87 men per game to cross the plate. That contrasts with Cleveland's No. 3-rated defense.