MLB Odds with Pick - Houston Astros vs Seattle Mariners

The Houston Astros will look to pick up a road win when they take on the Mariners in Seattle at Safeco Field on Wednesday in MLB baseball betting odds action.

Mike Fiers gets the ball in front of a hostile crowd for the Houston Astros on Wednesday; he's 0-1 on the season. The Seattle Mariners, meanwhile, will counter with Yovani Gallardo, who will be looking to improve on his 0-1 mark.

Sportsbook Odds & Computer Pick

Sportsbooks such as Sportsbook had installed the Seattle Mariners as 103 moneyline underdogs in this particular MLB betting odds matchup. The total, meanwhile, was set early at 8 before betting at Sportsbook started to move the line.

Prediction-scoring formulas run on this game pick a potential 5.4-3.5 result in favor of the Astros. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Houston Astros vs Seattle Mariners Matchup

Team Betting Records & Power Rankings

The Seattle Mariners bring a 2-7 record to the battle against the 5-4 Astros. Stay Informed: follow us on Twitter for odds specials, betting line moves and Seattle vs Houston injuries news.

This game matches up the No. 14 (Seattle Mariners) and the No. 26 (Houston Astros) teams, according to our current MLB Power Rankings.

Statistical Matchup

At the plate, Seattle owns the No. 25 ranking for hits at 7 per game. By contrast, the Houston Astros are rated No. 12 in the same category at 8.56 per game.

Pitching and defensive stats are important baseball handicapping betting factors and Seattle has the No. 17-ranked defense. In the other dugout, the Astros own the No. 10 mark in runs allowed.