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Interleague Baseball Handicapping Tips

Interleague play is back this weekend with a week-long run of AL versus NL matchups and a week-long run of money-making trends. Ever since interleague play was introduced in 1997, the American League has dominated the National League. Last season, the AL went 138-114 in interleague play. However, judging by the early results from this season's previous interleague schedule, the AL's dominance may finally be ending. During the short interleague period in May the NL came out on top with a 23-20 mark.

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That isn't exactly a crushing win for the NL, though, so don't be surprised if the AL strikes back over the next week of games. The team with the best record overall in interleague play are the Yankees, and they have what looks like an easy matchup against the NL's worst team, the Houston Astros. The Yanks actually went 1-2 against the Mets in May, while the Astros lost two of three versus the Rays.

[ Get all the matchups here at OddsShark.com, along with live line updates in the MLB Odds section ]

The best interleague series are always the rivalry matchups, and the schedule-makers haven't disappointed this weekend with three of them on tap: The White Sox and Cubs, Angels and Dodgers, and Athletics and Giants. White Sox vs. Cubs has been a pretty even matchup over the years (Cubs 11-9 in their last 20), but lately the White Sox have dominated their Chicago brethren.

The Sox have won three in a row and seven of their last nine against the Cubs. The Cubs are hosting this weekend's series so the Sox will lose their DH advantage, which could be a boon for the Cubs who are 12-8 in their last 20 against the Sox at Wrigley Field. The Angels and the Dodgers are also meeting up under NL rules, which will force the Angels to either bench hot-hitting DH Hideki Matsui or put the slow-footed Godzilla into the outfield.

The Angels are 13-7 in their last 20 against the Dodgers, but they are only 10-10 in their last 20 trips to Dodger Stadium. Both the Angels and Dodgers are on fire right now (Angels 6-1 last seven, and Dodgers 6-2 last eight) so this should a good series to watch. Oakland was the only team in baseball to go undefeated in their interleague matchup in May.

Oddly enough that series was also against the Giants, who they swept in three games at home. It was a different story the last time the A's visited San Francisco when the Giants whipped them in three-straight while outscoring them 15-3.

Total bettors should be interested in this series, as both the Giants and A's are low-scoring teams and all three games they played in May went UNDER the total. In their last 20 matchups the UNDER is 15-4-1.