Pittsburgh Pirates at San Francisco Giants Betting Lines and Pick

The San Francisco Giants host Pittsburgh on Wednesday, looking to pick up a win and improve their 39-63 mark against the 50-51 Pirates in MLB betting odds action at AT&T Park.

Jeff Samardzija gets the call for the San Francisco Giants and he will try to build on a 4-11 mark. In the other dugout, Trevor Williams brings a 4-4 ledger to the game for the Pittsburgh Pirates as he tries to quiet the Giants bats.

Sportsbook Odds & Computer Pick

The visiting Pittsburgh Pirates were 112 moneyline underdogs in this one earlier in the day at most online sportsbooks including Sportsbook. The total was 8.5 at Sportsbook for those preferring over under betting.

Odds Shark computer score prediction models pick a possible 6.5-5.8 win for the Pirates on Wednesday. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Pittsburgh Pirates vs San Francisco Giants Matchup

Team Betting Records & Power Rankings

The San Francisco Giants sport a record of 39-63 heading into this matchup, while the Pittsburgh Pirates sit at 50-51 on the season Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs Pittsburgh injuries news.

This game matches up the No. 24 (San Francisco Giants) and the No. 12 (Pittsburgh Pirates) teams, according to our current MLB Power Rankings.

Statistical Matchup

On offense, it's a battle between the San Francisco Giants and its No. 28-rated batting order, averaging 3.97 runs per nine innings, against the No. 23 line up of the Pittsburgh Pirates at 4.3 runs per outing.

Defensively, Pittsburgh features the No. 13-rated defense on the road, allowing 4.53 runs per game. San Francisco, meanwhile, comes in at No. 29 at home, scoring 3.72 runs per game.