On one side of the Final Four odds picture, its Louisville with Rick Pitino against Kentucky and the man who replaced Pitino for the Wildcats, John Calipari.
On the other side of the Final Four odds picture, its a pair of No. 2 seeds - Kansas battling Ohio State.
But the Louisville vs Kentucky betting line and the Ohio State vs Kansas point spread are hardly the only options for March Madness bettors this week.
"Expect literally thousands of prop bets on teams and players and expect sportsbooks to take a lot of betting action on Most Outstandings Player award odds as well," said Jack Randall.
"And just like the Final Four itself, where Kentucky is favored, the players expected to garner the most MOP betting action also wear Wildcat jerseys."
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Indeed, Anthony Davis remains the 3/2 favorite, despite hurting himself in Kentucky's Elite Eight win. His four teammates in the Wildcat starting lineup are the next four top choices.
However, the outcome that most worried sportsbooks was a Louisville victory.
“The way the Final Four matchups played out the book is in an overall pretty good position considering Kentucky, Ohio State and Kansas were among favorites all year," said Kevin Bradley of Bovada. "The one team that would not be a great result for us is Louisville but considering they are almost double digit underdogs to the Wildcats we like our chances."
The favorite matchup at even odds is a Kentucky vs Ohio State final next Monday.
Final Four Odds: to Win the 2012 NCAA Men's Basketball Championship
Ohio State 14/5
Exact Matchup for the 2012 NCAA Men's Basketball Championship
Kentucky vs Ohio State 1/1
Kentucky vs Kansas 7/4
Louisville vs Ohio State 13/2
Louisville vs Kansas 10/1
Odds to win the 2012 NCAA Men's Basketball Tournament MOP
Anthony Davis (Kentucky) 3/2
Michael Kidd-Gilchrist (Kentucky) 4/1
Doron Lamb (Kentucky) 15/1
Marquis Teague (Kentucky) 20/1
Terrence Jones (Kentucky) 25/1
Thomas Robinson (Kansas) 8/1
Tyshawn Taylor (Kansas) 15/1
Jared Sullinger (Ohio State) 11/2
DeShaun Thomas (Ohio State) 15/2
William Buford (Ohio State) 15/1
Peyton Siva (Louisville) 20/1
Kyle Kuric (Louisville) 25/1
Gorgui Dieng (Louisville) 25/1
Chane Behanan (Louisville) 35/1