In 10 March Madness brackets between 2002 and 2011, no 15 seed had upset a No. 2 seed.
But in 2012, it happened twice, throwing fear into bettors and throwing many brackets into disarray.
Norfolk State pulled off the biggest upset in modern March Madness history when they took out Missouri as 21-point underdogs. On the same day, Lehigh was defeating Duke 75-70 as 11-point underdogs.
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No 15 seed has made it to the Sweet 16. Check out the list of 2 vs 15 betting matchups dating back to 2001 (when Hampton upset Iowa State).
Also see 1 vs 16 stats, 2 vs 15 stats, 3 vs 14 stats, 4 vs 13 stats, 5 vs 12 stats, 6 vs 11 stats, 7 vs 10 stats and 8 vs 9 stats.
| Seed 1 | Score | Seed 2 | Score | Date | ATSWin | WinSeed | ATSWin |
| Kansas | 65 | Detroit | 50 | 2012-03-16 | Kansas | 2 | 2 |
| Duke | 70 | Lehigh | 75 | 2012-03-16 | Lehigh | 15 | 15 |
| Missouri | 84 | Norfolk State | 86 | 2012-03-16 | Norfolk State | 15 | 15 |
| Ohio State | 78 | Loyola | 59 | 2012-03-15 | Ohio State | 2 | 2 |
| North Carolina | 102 | Long Island | 87 | 2011-03-18 | Long Island | 2 | 15 |
| Notre Dame | 69 | Akron | 56 | 2011-03-18 | Akron | 2 | 15 |
| Florida | 79 | Santa Barbara | 51 | 2011-03-17 | Florida | 2 | 2 |
| San Diego State | 68 | Northern Colorado | 50 | 2011-03-17 | San Diego State | 2 | 2 |
| Ohio State | 68 | Santa Barbara | 51 | 2010-03-19 | Santa Barbara | 2 | 15 |
| West Virginia | 77 | Morgan State | 50 | 2010-03-19 | West Virginia | 2 | 2 |
| Kansas State | 82 | North Texas | 62 | 2010-03-18 | Kansas State | 2 | 2 |
| Villanova | 73 | Robert Morris | 70 | 2010-03-18 | Robert Morris | 2 | 15 |
| Michigan State | 77 | Robert Morris | 62 | 2009-03-20 | Michigan State | 2 | 2 |
| Oklahoma | 82 | Morgan State | 54 | 2009-03-19 | Oklahoma | 2 | 2 |
| Duke | 86 | Binghamton | 62 | 2009-03-19 | Duke | 2 | 2 |
| Memphis | 81 | CS Northridge | 70 | 2009-03-19 | CS Northridge | 2 | 15 |
| Texas | 74 | Austin Peay | 54 | 2008-03-21 | Texas | 2 | 2 |
| Georgetown | 66 | UMBC | 47 | 2008-03-21 | Georgetown | 2 | 2 |
| Tennessee | 72 | American | 57 | 2008-03-21 | American | 2 | 15 |
| Duke | 71 | Belmont | 70 | 2008-03-20 | Belmont | 2 | 15 |
| Wisconsin | 76 | Texas A&M C.C. | 63 | 2007-03-16 | Wisconsin | 2 | 2 |
| Memphis | 73 | North Texas | 58 | 2007-03-16 | North Texas | 2 | 15 |
| UCLA | 70 | Weber State | 42 | 2007-03-15 | UCLA | 2 | 2 |
| Georgetown | 80 | Belmont | 55 | 2007-03-15 | Georgetown | 2 | 2 |
| Texas | 60 | Pennsylvania | 52 | 2006-03-17 | Pennsylvania | 2 | 15 |
| Ohio State | 70 | Davidson | 62 | 2006-03-17 | Davidson | 2 | 15 |
| UCLA | 78 | Belmont | 44 | 2006-03-16 | UCLA | 2 | 2 |
| Tennessee | 63 | Winthrop | 61 | 2006-03-16 | Winthrop | 2 | 15 |
| Connecticut | 77 | Central Florida | 71 | 2005-03-18 | Central Florida | 2 | 15 |
| Oklahoma State | 63 | Southeastern Louisiana | 50 | 2005-03-18 | Southeastern Louisiana | 2 | 15 |
| Wake Forest | 70 | Chattanooga | 54 | 2005-03-17 | Chattanooga | 2 | 15 |
| Kentucky | 72 | Eastern Kentucky | 64 | 2005-03-17 | Eastern Kentucky | 2 | 15 |
| Mississippi State | 85 | Monmouth | 52 | 2004-03-19 | Mississippi State | 2 | 2 |
| Oklahoma State | 75 | Eastern Washington | 56 | 2004-03-19 | Oklahoma State | 2 | 2 |
| Gonzaga | 76 | Valparaiso | 49 | 2004-03-18 | Gonzaga | 2 | 2 |
| Connecticut | 70 | Vermont | 53 | 2004-03-18 | Vermont | 2 | 15 |
| Wake Forest | 76 | East Tennessee State | 73 | 2003-03-21 | East Tennessee State | 2 | 15 |
| Pittsburgh | 87 | Wagner | 61 | 2003-03-21 | Pittsburgh | 2 | 2 |
| Florida | 85 | Sam Houston State | 55 | 2003-03-21 | Florida | 2 | 2 |
| Kansas | 64 | Utah State | 61 | 2003-03-20 | Utah State | 2 | 15 |
| Oklahoma | 71 | Illinois-Chicago | 63 | 2002-03-15 | Illinois-Chicago | 2 | 15 |
| Connecticut | 78 | Hampton | 67 | 2002-03-15 | Hampton | 2 | 15 |
| Alabama | 86 | Florida Atlantic | 78 | 2002-03-14 | Florida Atlantic | 2 | 15 |
| Oregon | 81 | Montana | 62 | 2002-03-14 | Montana | 2 | 15 |
| Arizona | 101 | Eastern Illinois | 76 | 2001-03-16 | Arizona | 2 | 2 |
| North Carolina | 70 | Princeton | 48 | 2001-03-16 | North Carolina | 2 | 2 |
| Kentucky | 72 | Holy Cross | 68 | 2001-03-15 | Holy Cross | 2 | 15 |
| Iowa State | 57 | Hampton | 58 | 2001-03-15 | Hampton | 15 | 15 |







