Only once in the past 12 March Madness tournament has the No. 5 seeds shut out the 12 seeds and that was back in 2007.
Most years, a pair of 12 seeds upset their neighbors at No. 5 in the bracket. And last year was no different, as South Florida and VCU each pulled the upsets.
In the past 18 battles of 5 vs 12, the underdogs are 12-6 ATS, according to our database.
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However, 12 seeds seldom advance deep into the tournament. Only one team has made the Elite Eight (Missouri back in 2002).
Check out the full list of 5 vs 12 seed matchups dating back to 2001. And watch for point spreads and totals on every NCAA hoops game every day.
Also see 1 vs 16 stats, 2 vs 15 stats, 3 vs 14 stats, 4 vs 13 stats, 5 vs 12 stats, 6 vs 11 stats, 7 vs 10 stats and 8 vs 9 stats.
| Seed 1 | Score | Seed 2 | Score | Date | ATSWin | WinSeed | ATSWin |
| Temple | 44 | South Florida | 58 | 2012-03-16 | South Florida | 12 | 12 |
| Wichita State | 59 | Virginia Commonwealth | 62 | 2012-03-15 | Virginia Commonwealth | 12 | 12 |
| Vanderbilt | 79 | Harvard | 70 | 2012-03-15 | Vanderbilt | 5 | 5 |
| New Mexico | 75 | Long Beach State | 68 | 2012-03-15 | New Mexico | 5 | 5 |
| Arizona | 77 | Memphis | 75 | 2011-03-18 | Memphis | 5 | 12 |
| Kansas State | 73 | Utah State | 68 | 2011-03-17 | Kansas State | 5 | 5 |
| Vanderbilt | 66 | Richmond | 69 | 2011-03-17 | Richmond | 12 | 12 |
| West Virginia | 84 | Clemson | 76 | 2011-03-17 | West Virginia | 5 | 5 |
| Michigan State | 70 | New Mexico State | 67 | 2010-03-19 | New Mexico State | 5 | 12 |
| Texas A&M | 69 | Utah State | 53 | 2010-03-19 | Texas A&M | 5 | 5 |
| Temple | 65 | Cornell | 78 | 2010-03-19 | Cornell | 12 | 12 |
| Butler | 77 | Texas El Paso | 59 | 2010-03-18 | Butler | 5 | 5 |
| Florida State | 59 | Wisconsin | 61 | 2009-03-20 | Wisconsin | 12 | 12 |
| Utah | 71 | Arizona | 84 | 2009-03-20 | Arizona | 12 | 12 |
| Illinois | 72 | Western Kentucky | 76 | 2009-03-19 | Western Kentucky | 12 | 12 |
| Purdue | 61 | Northern Iowa | 56 | 2009-03-19 | Northern Iowa | 5 | 12 |
| Clemson | 69 | Villanova | 75 | 2008-03-21 | Villanova | 12 | 12 |
| Drake | 99 | Western Kentucky | 101 | 2008-03-21 | Western Kentucky | 12 | 12 |
| Notre Dame | 68 | George Mason | 50 | 2008-03-20 | Notre Dame | 5 | 5 |
| Michigan State | 72 | Temple | 61 | 2008-03-20 | Michigan State | 5 | 5 |
| USC | 77 | Arkansas | 60 | 2007-03-16 | USC | 5 | 5 |
| Virginia Tech | 54 | Illinois | 52 | 2007-03-16 | Illinois | 5 | 12 |
| Tennessee | 121 | Long Beach State | 86 | 2007-03-16 | Tennessee | 5 | 5 |
| Butler | 57 | Old Dominion | 46 | 2007-03-15 | Butler | 5 | 5 |
| Pittsburgh | 79 | Kent State | 64 | 2006-03-17 | Pittsburgh | 5 | 5 |
| Washington | 75 | Utah State | 61 | 2006-03-16 | Washington | 5 | 5 |
| Syracuse | 58 | Texas A&M | 66 | 2006-03-16 | Texas A&M | 12 | 12 |
| Nevada | 79 | Montana | 87 | 2006-03-16 | Montana | 12 | 12 |
| Michigan State | 89 | Old Dominion | 81 | 2005-03-18 | Michigan State | 5 | 5 |
| Georgia Tech | 80 | George Washington | 68 | 2005-03-18 | Georgia Tech | 5 | 5 |
| Villanova | 55 | New Mexico | 47 | 2005-03-18 | Villanova | 5 | 5 |
| Alabama | 73 | Wisc-Milwaukee | 83 | 2005-03-17 | Wisc-Milwaukee | 12 | 12 |
| Providence | 58 | Pacific | 66 | 2004-03-19 | Pacific | 12 | 12 |
| Illinois | 72 | Murray State | 53 | 2004-03-19 | Illinois | 5 | 5 |
| Syracuse | 80 | BYU | 75 | 2004-03-18 | Syracuse | 5 | 5 |
| Florida | 60 | Manhattan | 75 | 2004-03-18 | Manhattan | 12 | 12 |
| Mississippi State | 46 | Butler | 47 | 2003-03-21 | Butler | 12 | 12 |
| Notre Dame | 70 | Wisc-Milwaukee | 69 | 2003-03-20 | Wisc-Milwaukee | 5 | 12 |
| Connecticut | 58 | BYU | 53 | 2003-03-20 | Connecticut | 5 | 5 |
| Wisconsin | 81 | Weber State | 74 | 2003-03-20 | Wisconsin | 5 | 5 |
| Florida | 82 | Creighton | 83 | 2002-03-15 | Creighton | 12 | 12 |
| Miami | 80 | Missouri | 93 | 2002-03-14 | Missouri | 12 | 12 |
| Indiana | 75 | Utah | 56 | 2002-03-14 | Indiana | 5 | 5 |
| Marquette | 69 | Tulsa | 71 | 2002-03-14 | Tulsa | 12 | 12 |
| Syracuse | 79 | Hawaii | 69 | 2001-03-16 | Syracuse | 5 | 5 |
| Virginia | 85 | Gonzaga | 86 | 2001-03-16 | Gonzaga | 12 | 12 |
| Ohio State | 68 | Utah State | 77 | 2001-03-15 | Utah State | 12 | 12 |
| Cincinnati | 84 | BYU | 59 | 2001-03-15 | Cincinnati | 5 | 5 |
