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Louisville vs Oregon Sweet 16 Prediction

The No. 1 Louisville Cardinals easily won their first two games of the NCAA Tournament, and now they are huge favorites against No. 12 Oregon Ducks in Sweet 16 betting action in Indianapolis on Friday.

And the Cardinals have been on fire against the spread, going 6-0-1 ATS in their past seven Madness games and 6-0 ATS in their past six Sweet 16 games.

As favorites, they are on an 8-0 ATS and they have covered the spread in nine straight games overall.

The Cardinals topped Colorado State 83-55 in their Round of 32 matchup, paying off at the sportsbooks as a favorite of 10.5 points in that contest. Oregon is coming off a 74-57 win over Saint Louis last round as a betting underdog of 4.5 points.

Supporters of the Ducks have watched them go 28-8 and 15-17-2 ATS on the year, while the Cardinals are at 31-5 and 22-13-1 ATS. In totals betting, the Cardinals are 17-16, while the Ducks have a 13-17 mark.

View Oregon vs Louisville Odds and Stats.

Louisville vs Oregon Betting Line: The Cardinals were favored by 10.5 at Bovada earlier while the total for this game was hovering near 129.5 at 5Dimes.

Power Rankings / Prediction:
This game puts the Cardinals, most recently No. 1 in the Odds Shark power rankings, up against the Ducks, who rate No. 57 in the latest survey. Meanwhile, math and computer-based handicapping simulations run on this game predict a potential 83-75 victory for the Cardinals.

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How They Match Up:
The game also pits Louisville's No. 35-ranked offense, averaging 73.9 PPG, against a Ducks defense that ranks No. 86 at 63.2 PPG. The Cardinals field goal percentage has averaged 45.2% so far, more than the Ducks marksmen have achieved on the year, 44.8% per game.

Defensively, Oregon features the nation's No. 168-rated defense on the road, allowing 69.2 points per game. Louisville, meanwhile, comes in at No. 63 nationally in scoring at home.

Oregon was a 74-57 winner in its last match on the road against Saint Louis. They covered the 5-point spread as underdogs. Damyean Dotson scored 23 points leading the Ducks to a 74-57 victory over Saint Louis at HP Pavilion on Saturday.

Last time out for Louisville, they were an 83-55 winner as they battled Colorado State at home. They covered in the match as a 10.5-point favorite. Louisville cruised to victory on Saturday, running Colorado State out of the gym and running up an 83-55 score at Rupp Arena.