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Louisville vs Michigan State: West Odds

Michigan State is money in the bank when they hit the Sweet 16, as their 5-0 ATS in five recent trips indicates.

But what about Louisville, the Rick Pitino-coached squad, that opened as 4.5 point West Regional Sweet 16 underdogs?

While the Spartans enjoy that Sweet 16 success rate, the Cardinals have won and covered 6 straight games and have been very tough as an underdog (8-3 ATS past 11 times).

[ Watch West Region odds updates and Sweet 16 special offers at TopBet ]

The Spartans bring a 29-7 record (23-11 ATS) to this tilt against the 28-9 Cardinals, who are 20-13-1 ATS. OVER/UNDER bettors have witnessed Michigan State go 17-15-2 so far and the Cardinals go 13-20-1.

View Louisville vs Michigan State Odds and Stats.

Power Rankings / Prediction:
The Spartans - Cardinals odds would favor the Spartans if the lines were set according to our power ranks. Michigan State is rated No. 1 in the current Odds Shark poll, while Louisville is at No. 7. Mathematical models based on recent stats and predictive formulas point to a 78-73 win for the Spartans.

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How They Match Up:
Rebounding is always a key handicapping consideration and Cardinals is ranked No. 28 in NCAA hoops at 37.9 per game. Contrast that with Michigan State’s No. 26 mark in the paint. When it comes to three-point shooting, Michigan State is the No. 243-ranked team in the country at 5.4 per game, while Louisville rates No. 210 at 5.8 per game.

Defensively, Louisville features the nation's No. 46-rated defense on the road, allowing 64 points per game. Michigan State, meanwhile, comes in at No. 62 nationally in scoring at home.

Louisville was a 59-56 winner in its last match at home against New Mexico. They covered the 2-point spread as favorites. Louisville got 17 points from Russ Smith en route to a 59-56 victory over New Mexico on Saturday at Rose Garden.

In their last action, Michigan State was a 65-61 winner at home against Saint Louis. They failed to cover the 7-point spread as favorites. Keith Appling scored 19 points leading the Spartans to a 65-61 victory over Saint Louis at Nationwide Arena on Sunday.