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College Football Week 4 Potential Upsets

The 2-0 Florida State Seminoles are sitting as 16.5-point favorites ahead of their Saturday night matchup with the Clemson Tigers. The Seminoles are coming off a bye in Week 3 following a pair of SU wins, but ATS losses, against Oklahoma State and The Citadel.

The Tigers are Florida State’s first ranked opponent of the season, but the Seminoles have enjoyed recent success against them, 8-1 SU and 6-3 ATS in their last nine meetings.

Clemson is also coming off a bye following a 1-1 start, SU and ATS, including a 45-21 loss to Georgia on the road followed by a 73-7 thrashing of South Carolina State a week later.

This Clemson team is a little younger than the squad that was pummeled 51-14 last season. However, they are no stranger to big games, and the Seminoles could be vulnerable without quarterback Jameis Winston, who is suspended for the first half on Saturday.

Editor's Note: Winston was suspended for the entire game vs. Clemson late on Friday night.

Matchup Reports: Clemson vs. Florida State | Oklahoma vs. West Virginia | FIU vs. Louisville

The 2-1 West Virginia Mountaineers hope to continue their strong start when they take on the Oklahoma Sooners as 7.5-point home underdogs in college football betting at Bovada.

Led by quarterback Clint Trickett, who has already thrown for 1224 yards and seven TDs, the Mountaineers are 3-0 ATS on the year following a 40-37 win over Maryland as 3-point road dogs in Week 3.

While the Sooners are 7-0 SU and 6-1 ATS in their last seven, they have disappointed college football bettors in their most recent games against West Virginia, 2-1 SU and 0-3 ATS in their last three meetings.

With a combined 251 points so far this season, neither team has trouble generating offense, giving this game shootout potential that could work to the advantage of a home underdog on a roll.

After suffering an upset 23-21 loss to Virginia last week, the 2-1 Louisville Cardinals are heavy 27-point favorites against the 1-2 Florida International Golden Panthers.

While the Cardinals are a beastly 14-2 SU in their last 16, they are a meagre 5-7 ATS in their last 12, and 2-6 ATS in their last eight as double-digit favorites, including outright losses to Virginia and Central Florida.

Just 2-9 SU in their last 11, FIU are far from world beaters. However, a little defense could go a long way for the Golden Panthers, who are 4-0 ATS in their last four, and 6-3 ATS in their last nine when the UNDER carries the day.

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