Pittsburgh Panthers vs Syracuse Orange Week 6 Betting Prediction and Odds

A key Week 6 battle has the visiting Pittsburgh Panthers travelling to Syracuse on Saturday to face the Orange.

Sportsbook Odds & Computer Pick

Betting fans going with the Syracuse Orange in this game found them listed as -2-point favorites on the betting odds menu at Sportsbook earlier in the week.

Earlier, Odds Shark computer prediction handicapping models run on this game picked a 33-27 victory for the Panthers. That score may change during the week, if injury or weather factors alter the numbers, so check the college football picks page before game time. View the computer score prediction and who will win the pick on the moneyline for all upcoming NCAAF matchups here.

Pittsburgh Panthers vs Syracuse Orange Matchup

Team Betting Records & Power Rankings

The Syracuse Orange are 2-3 so far on the season, and 3-2 ATS vs the point spread. The Pittsburgh Panthers, meanwhile, are 2-3 and 1-3-1 ATS. Those over under betting have seen Syracuse go 1-4 and the Pittsburgh Panthers go 1-3-1 on the totals. Stay Informed: follow us on Twitter for odds specials, betting line moves and Syracuse vs Pittsburgh injuries news.

This game matches up the No. 91 (Syracuse Orange) and the No. 71 (Pittsburgh Panthers) teams in the league, according to our current NCAA football Power Rankings at Odds Shark.

Statistical Matchup

The game also pits Syracuse's No. 54-ranked offense, averaging 33 PPG, against a Pittsburgh defense that ranks No. 101 this week at 31.6 PPG. The Syracuse aerial game is averaging 317 yards per game, more than the Pittsburgh Panthers secondary allows through the air, 263.4 YPG per game.

Defensively, the Pittsburgh Panthers feature the league's No. 117-rated road run defense, allowing 292 yards per game. Syracuse, meanwhile, ranks No. 59 in rushing offense at home.