The Rams never win on the road and the 49ers almost always win at home - small wonder there is a huge point spread as St Louis visits San Francisco in Week 13 NFL betting action.

The Rams are a weak 2-7 SU in their past 9 trips to face their NFC West rivals 49ers. They have also lost 16 of their past 20 road games overall.

The 49ers meanwhile continue to haul in profits at home. They are 13-3-2 ATS past 18 home games and are 14-4 SU during those games.

San Fran is also 9-0 SU and ATS in their past 9 games as chalk, while the Rams are 2-8 SU and ATS past 10 as an NFL underdog.



View St Louis vs San Francisco Odds and Stats.

Betting Line:
The Rams are listed as 13.5-point underdogs at sportsbooks, with the total listed at 38.





How They Match Up:
Offensively, the game matches up San Francisco's No. 9-ranked offense (23.8 PPG) against a Rams defense that ranks No. 24 at 24.5 PPG. The 49ers passing attack has averaged 179.9 yards per game, less than the Rams give up through the air (205.1 YPG on average).

Defensively, the Rams feature the league's No. 26-rated road run defense, allowing 139.8 yards per game. San Francisco, meanwhile, ranks No. 8 in rushing offense at home.

The Rams were a 23-20 loser in their most recent outing at home against the Cardinals. They failed to cover the 2.5–point spread as favorites, while the total score (43) made winners of OVER bettors. The Rams suffered a Week 12 loss against Arizona in their last game, falling 23-20 at Edward Jones Dome.

San Francisco lost its last outing, a 16-6 result against the Ravens on November 24. The 49ers failed to cover in that game as a 3.5-point underdog, while the 22 combined points took the game UNDER the total. The 49ers suffered a Week 12 loss against Baltimore in their last game, falling 16-6 at M&T Bank Stadium.


St. Louis Rams Trends:
When playing in December are 2-8
When playing on grass are 3-7
After being outgained are 4-6
When playing within the division are 3-7

San Francisco 49ers Trends:
When playing in December are 5-5
When playing on grass are 8-2
After being outgained are 7-3
When playing within the division are 8-2

A few Rams at 49ers trends to consider:
The total has gone UNDER in 7 of St. Louis's last 8 games on the road
The total has gone UNDER in 6 of St. Louis's last 8 games
The total has gone UNDER in 7 of St. Louis's last 10 games when playing San Francisco
St. Louis is 4-9 ATS in its last 13 games when playing San Francisco
San Francisco is 8-1 SU in its last 9 games
San Francisco is 7-0-1 ATS in its last 8 games at home
San Francisco is 7-1 SU in its last 8 games at home
The total has gone UNDER in 5 of San Francisco's last 6 games


Next up:
St. Louis at Seattle, Monday, December 12
San Francisco at Arizona, Sunday, December 11