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Bills open as underdog vs Saints

Buffalo Bills New Orleans Saints

Coming off their bye week the 5-1 New Orleans Saints probably can't wait to get back on the field, after giving away that game at New England a couple weeks ago.

The potential recipients of the Saints' wrath this week are the 3-4 Buffalo Bills, who, after winning in Miami, visit the Superdome for an inter-conference match-up this Sunday (1 pm ET, CBS).

New Orleans owns a two-game lead in the NFC South, and is only a half-game behind Seattle in the battle for the best record in the NFC. The Saints are also 4-2 ATS on the season.

Buffalo, with back-up Thaddeus Lewis at quarterback, just upset the Dolphins as six-point underdogs. So the Bills are now 5-2 ATS on the year.

As of early this week New Orleans, which is only 3-8 ATS over its last 11 games as a double-digit favorite, was favored by 12 points over Buffalo.

The Saints currently sport a record of 5-1, and have posted a corresponding betting slate of 4-2 ATS. The Bills are 3-4 and 5-2 ATS. Betting totals have seen the Saints post a 2-4 over under record this season, while the Bills have gone 5-2 against the number.

View Buffalo Bills vs New Orleans Saints Odds and Stats.

On the opening line for this matchup, the Saints sat as -11.5-point favorites at shops such as 5Dimes. The total, meanwhile, has been pegged by the oddsmakers at GTbets.eu at 50.

This game matches up the No. 5 (Saints) and the No. 24 (Bills) teams in the league, according to our current NFL Power Rankings at OddsShark. A 30-19 result in favor of the Saints is predicted by handicapping models.

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Buffalo was a 23-21 winner in its last match on the road against the Dolphins. They covered the 5.5-point spread as underdogs, while the total score of 44 sent OVER bettors to the payout window. The Bills grabbed a Week 7 victory over the Dolphins in their last game, winning 23-21 at Sun Life Stadium. Last time out, New Orleans got 2 scoring strikes from Drew Brees in a 30-27 loss against New England.

How They Match Up:
Offensively, the game matches up New Orleans's No. 6-ranked offense (26.83 PPG) against a Bills defense that ranks No. 22 at 25.43 PPG. The Saints passing attack has averaged 311 yards per game, more than the Bills give up through the air (256.86 YPG on average).

Defensively, the Bills feature the league's No. 26-rated road run defense, allowing 131 yards per game. New Orleans, meanwhile, ranks No. 25 in rushing offense at home.

A few Bills at Saints trends to consider:
Buffalo is 5-13-1 SU in its last 19 games
Buffalo is 1-4 ATS in its last 5 games on the road
Buffalo is 1-6 SU in its last 7 games on the road
The total has gone OVER in 4 of Buffalo's last 6 games on the road
New Orleans is 4-1-1 SU in its last 6 games
New Orleans is 4-1 ATS in its last 5 games at home
New Orleans is 4-1 SU in its last 5 games at home
New Orleans is 4-2 ATS in its last 6 games when playing Buffalo

Next up:
Buffalo at Kansas City, Sunday, November 3rd
New Orleans at New York, Sunday, November 3rd