The San Francisco 49ers will be aiming for their first SU win at home since Week 1 of 2016 when they host the Carolina Panthers in a season-Sportsbook matchup at Levi’s Stadium. The 49ers have covered just once during their current 0-7 SU run on home turf, but host a Panthers squad that tallied just two SU road wins last season.
The Panthers struggled to generate offense on the road last season, averaging just 16 points per game over their final five dates away from Bank of America Stadium. Carolina also surrendered a whopping 37.5 points per game over its past two visits to the West Coast, falling to defeat against Oakland and Seattle in the second half of the 2016 campaign.
Following a brutal 2-14 SU campaign in 2016, the 49ers have nowhere to go but up. San Francisco has lost by an average margin of 10.7 points during its current slide at home, but closed that gap in the final two home dates, including a narrow 25-23 loss to Seattle in Week 17.
However, Carolina has emerged as a reliable bet in recent meetings with the 49ers, going 13-2 ATS over their past 15 matchups.
Sportsbook Odds & Computer Pick
Bettors who were going with the San Francisco 49ers in this one found them listed as 4-point underdogs on the betting line at Sportsbook. Fans betting on totals have seen that number set earlier in the week at 48.5 for Sunday.
OddsShark NFL prediction models pointed to a 24-18 result in favor of the 49ers on Sunday. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.
Carolina Panthers vs San Francisco 49ers Matchup
Team Betting Records & Power Rankings
The Carolina Panthers will look to cover ATS vs their hosts on Sunday, as they were 6-8-2 ATS versus the spread last season, while the San Francisco 49ers were 4-11-1 ATS. Carolina was 8-8 against the OVER/UNDER total, while San Francisco was 10-6 versus the number. Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs Carolina injuries news.
The 49ers-Panthers odds would favor the Panthers if the betting lines were set according to power ranks. San Francisco is rated No. 30 in our latest OddsShark poll, while the Panthers sit at No. 27.
Statistical Matchup
Offensively, the game matches up the San Francisco 49ers No. 26-ranked offense last season (19.31 PPG) against a Carolina Panthers defense that ranked No. 26 at 25.12 PPG. The 49ers passing attack averaged 181.94 yards per game, less than the Panthers gave up through the air (268.19 YPG on average).
Defensively, the Carolina Panthers featured the league's No. 9-rated road run defense, allowing 99.5 yards per game. The San Francisco 49ers, meanwhile, ranked No. 4 in rushing offense at home.
Recent Outings Betting Recap
In their last game, the Panthers were Week 17 losers coming out on the wrong end of 17-16 score against Tampa Bay.
Shaun Draughn scored twice in San Francisco's most recent game, but it still resulted in a loss, 25-23 versus Seattle at Levi's Stadium.
Next Betting Matchups
Carolina home to Buffalo, Sunday, September 17
San Francisco at Seattle, Sunday, September 17