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Game Preview - Rams underdogs vs 49ers at St. Louis

San Francisco 49ersSt. Louis Rams
Dec 2, 1:00 PM | Turf of Edward Jones Dome

San Francisco 49ers vs St. Louis Rams Odds

8-2-1TEAM RECORD4-6-1

After playing to the NFL's first tie since 2008 in Week 10, the San Francisco 49ers and St. Louis Rams will meet again Sunday, this time at the Edward Jones Dome in St. Louis. San Francisco is 7-1-1 SU in its last nine games against St. Louis.

While St. Louis is just 1-3-1 SU in its last five games against San Francisco it is 4-1 ATS over that stretch. The total has gone OVER in each of St. Louis's last five games and in each of San Francisco's last three.

View San Francisco vs St Louis Odds and Stats.

Betting Line:
Sportsbooks such as Bovada had the Rams pegged as 6.5-point underdogs in this matchup. The total, meanwhile, was listed by books like TopBet at 41.

Power Rankings / Prediction:
The Rams - 49ers odds would favor the 49ers if the lines were set according to power ranks. St. Louis is rated No. 19 in our latest OddsShark poll, while the 49ers sit at No. 2. Math models based on recent stats and predictive formulas point to a 31-16 win for the 49ers.

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How They Match Up:
Offensively, the game matches up St. Louis's No. 28-ranked offense (18.6 PPG) against a 49ers defense that ranks No. 1 at 14.1 PPG. The Rams passing attack has averaged 212.9 yards per game, more than the 49ers give up through the air (187.3 YPG on average).

Defensively, the 49ers feature the league's No. 1-rated road run defense, allowing 60.4 yards per game. St. Louis, meanwhile, ranks No. 17 in rushing offense at home.

Last time out for San Francisco, they were a 31-21 winner as they battled the Saints on the road. The 49ers covered in the match as a 2-point favorite, while 52 combined points moved the game OVER for totals bettors. In their last game, the 49ers were Week 12 winners, coming out on top of the Saints by a score of 31-21.

St. Louis won its last outing, a 31-17 result against the Cardinals on November 25. The Rams covered in that game as a 1-point underdog, while the 48 combined points took the game OVER the total. Arizona was unable to contain Steven Jackson in its last action Sunday and the result was a 31-17 Week 12 loss against the Rams.

San Francisco 49ers Trends:
When playing in December are 5-5
When playing on turf are 6-4
After outgaining opponent are 6-3-1
When playing on within the division are 8-1-1

St. Louis Rams Trends:
When playing in December are 2-8
When playing on turf are 3-7
After being outgained are 4-5-1
When playing on within the division are 3-6-1

A few 49ers at Rams trends to consider:
San Francisco is 6-1 SU in its last 7 games on the road
San Francisco4-0-1 SU in its last 5 games
The total has gone OVER in 4 of San Francisco's last 5 games when playing St. Louis
San Francisco is 4-1 SU in its last 5 games when playing on the road against St. Louis
The total has gone OVER in 5 of St. Louis's last 5 games
The total has gone OVER in 4 of St. Louis's last 5 games when playing San Francisco
The total has gone OVER in 5 of St. Louis's last 7 games at home
The total has gone UNDER in 4 of St. Louis's last 6 games when playing at home against San Francisco

Next up:
San Francisco home to Miami, Sunday, December 9
St. Louis at Buffalo, Sunday, December 9