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Giants vs 49ers Game Preview

All the San Francisco 49ers fans who continue to bet against the team may finally be learning their lesson here in Week 10.

The NFC West-leading 49ers host the New York Giants, opening as 3.5-point home favorites over a team coming off an emotional high after beating the Patriots. Head to head, the Giants have dominated the series going 5-1-1 ATS past 7 vs SF.

But the 49ers have been excellent this season, winning at a 5-0-1 ATS clip past 6 games at home and rolling to a money-making 7-0 ATS mark the past 7 games as favorites.

View NY Giants vs San Francisco Odds and Stats.

Betting Line:
Sportsbooks have set the 49ers as 3.5-point favorites on the opening line for this contest. The total is listed at 43.5. The best Giants underdog line was at Bovada Saturday at +3.5, check it out plus dozens of Giants vs 49ers player props odds before kickoff.

Power Rankings / Prediction:
The OddsShark Power Rankings have the 49ers at No. 7 and the Giants at No. 17 heading into this contest. Handicapping models project a 33-24 result in favor of the 49ers.

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How They Match Up:
The game also pits San Francisco's No. 8-ranked offense, averaging 25.8 PPG, against a Giants defense that ranks No. 20 this week at 23 PPG. The 49ers aerial game is averaging 173.5 yards per game, less than the Giants secondary allows through the air, 238.5 YPG per game.

Defensively, the Giants feature the league's No. 20-rated road run defense, allowing 128.2 yards per game. San Francisco, meanwhile, ranks No. 7 in rushing offense at home.

In their last action, New York was a 24-20 winner on the road against the Patriots. They covered the 9.5–point spread as underdogs, while the combined score (44) was profitable news for UNDER bettors. Eli Manning passed for 2 touchdowns in his team's last game in leading the Giants past New England 24-20 on Sunday.

Last time out for San Francisco, they were a 19-11 winner as they battled the Redskins on the road. The 49ers covered in the match as a 5.5-point favorite, while 30 combined points moved the game UNDER for totals bettors. Frank Gore ran through the Washington defense for 107 yards in San Francisco's last game, handing the Redskins a 19-11 setback on Sunday at FedExField.

New York Giants Trends:
When playing in November are 5-5
When playing on grass are 5-5
After being outgained are 6-4
When playing outside the division are 8-2

San Francisco 49ers Trends:
When playing in November are 6-4
When playing on grass are 7-3
After outgaining opponent are 5-5
When playing outside the division are 6-4

A few Giants at 49ers trends to consider:
NY Giants are 6-1 SU in their last 7 games
NY Giants are 4-1 SU in their last 5 games on the road
NY Giants are 4-0-1 ATS in their last 5 games when playing San Francisco
The total has gone UNDER in 5 of the NY Giants last 7 games when playing San Francisco
San Francisco is 5-0 SU in its last 5 games
San Francisco is 5-0-1 ATS in its last 6 games at home
San Francisco is 5-1 SU in its last 6 games at home
The total has gone OVER in 5 of San Francisco's last 6 games at home

Next up:
NY Giants home to Philadelphia, Sunday, November 20
San Francisco home to Arizona, Sunday, November 20