The San Diego Chargers have faced Detroit six times in the past 30 years and never lost, but it's the Lions who are favored on the Week 16 NFL odds menu at most online sportsbooks.

The Chargers are making their perennial second-half push where they are 18-2 SU in their past 20 December games dating back to 2007, but they may have left it too late. They have been OVER machines on the road lately with an 8-1-1 mark in 10 games away from San Diego.

Detroit meanwhile is just 1-4 ATS at home in their past 5 after a stunning run of ATS victories at Ford Field.

The Lions are 11-2 SU in 13 games as a favorite.



View San Diego vs Detroit Odds and Stats.

Betting Line:
If you're siding with the visitors in this one you'll find the Chargers listed as 3-point underdogs. Meanwhile, the over under line for the matchup was at 50.5.

Power Rankings / Prediction:
The game pits the Lions, currently No. 14 in our OddsShark NFL Power Rankings, against the Chargers, who rate No. 9 in the latest survey. Meanwhile, math and handicapping models run on this game predict a 29-28 victory for the Lions.



How They Match Up:
Offensively, the game matches up Detroit's No. 4-ranked offense (28.2 PPG) against a Chargers defense that ranks No. 20 at 22.4 PPG. The Lions passing attack has averaged 282.8 yards per game, more than the Chargers give up through the air (201.5 YPG on average).

Defensively, the Chargers feature the league's No. 19-rated road run defense, allowing 122.2 yards per game. Detroit, meanwhile, ranks No. 18 in rushing offense at home.

In their last action, San Diego was a 34-14 Sportsbook at home against the Ravens. They covered the 1–point spread as underdogs, while the combined score (48) was profitable news for OVER bettors.

In their last action, Detroit was a 28-27 Sportsbook on the road against the Raiders. They failed to cover the 2.5–point spread as favorites, while the combined score (55) was profitable news for OVER bettors. Matthew Stafford dusted the Raiders secondary for 4 TDs last time out as the Lions defeated Oakland 28-27 at O.co Coliseum.


San Diego Chargers Trends:
When playing in December are 8-2
When playing on turf are 3-7
After outgaining opponent are 5-5
When playing outside the division are 5-5

Detroit Lions Trends:
When playing in December are 5-5
When playing on turf are 6-4
After being outgained are 5-5
When playing outside the division are 7-3

A few Chargers at Lions trends to consider:
San Diego is 5-0 SU in its last 5 games when playing Detroit
The total has gone OVER in 7 of San Diego's last 8 games on the road
San Diego is 3-6 SU in its last 9 games
San Diego is 2-4 SU in its last 6 games on the road
Detroit is 13-5 SU in its last 18 games
The total has gone OVER in 5 of Detroit's last 7 games
Detroit is 6-3 SU in its last 9 games at home
The total has gone UNDER in 4 of Detroit's last 6 games at home


Next up:
San Diego at Oakland, Sunday, January 1
Detroit at Green Bay, Sunday, January 1