Tony Romo and the Dallas Cowboys will be looking for a win as an underdog on the NFL betting lines on Wednesday night as the season gets started at MetLife Stadium.
That's just one of 16 games on the National Football League slate for this week, with 13 more games on Sunday and another two on tap in a Monday Night Football doubleheader. Here's a look at the week's opening lines . . .
Week 1 Opening NFL Betting Lines (from 5Dimes)
Wed - Dallas at N.Y. Giants (-4) (8:30pm ET)
Sun - Philadelphia at Cleveland (+9) (1:00pm ET)
Sun - Washington at New Orleans (-10) (1:00pm ET)
Sun - Atlanta at Kansas City (+1) (1:00pm ET)
Sun - St. Louis at Detroit (-9) (1:00pm ET)
Sun - Indianapolis at Chicago (-11) (1:00pm ET)
Sun - Jacksonville at Minnesota (-4.5) (1:00pm ET)
Sun - New England at Tennessee (+7) (1:00pm ET)
Sun - Miami at Houston (-12) (1:00pm ET)
Sun - Buffalo at N.Y. Jets (-2.5) (1:00pm ET)
Sun - Seattle at Arizona (+1.5) (4:25pm ET)
Sun - Carolina at Tampa Bay (+1) (4:25pm ET)
Sun - San Francisco at Green Bay (-5) (4:25pm ET)
Sun - Pittsburgh at Denver (pick) (8:20pm ET)
Mon - Cincinnati at Baltimore (-6) (7:00pm ET)
Mon - San Diego at Oakland (pick) (10:15pm ET)
Week 1 NFL Betting Trends and Notes
The Giants have been a profitable team in games against the Cowboys over the last five years, going 7-3 SU and 7-3 ATS over the past 10 meetings between the NFC East rivals. Last season Dallas didn't cover in either of their losses to New York.
The Browns are one of five home underdogs on the opening NFL betting lines for Week 1; the Chiefs, Titans, Cardinals, and Buccaneers are also getting points at home, while the Broncos and Raiders opened as home pick'ems.
The Texans are the biggest favorites on the opening Week 1 NFL betting lines at 5Dimes, as they're at -12 at home against the Dolphins. The Dolphins are 0-6 against the Texans franchise since 2003, covering the spread in just two of those six games.
The Bears are also big favorites for this weekend, giving 11 points to the visiting Colts and rookie quarterback Andrew Luck. Chicago and Indy haven't met since 2008, when the Bears won 29-13 on the road as a 10.5-point underdog.
The 49ers have lost eight straight games against the Packers dating back to 1999, going 1-6-1 ATS on the NFL betting lines at 5Dimes in those contests. The teams have played three straight OVER results.
The Bengals will be looking to break a three-game losing streak against the Ravens on Monday night, although they're 4-1-1 against the spread in their last six games against Baltimore. Both the Bengals and Ravens made the playoffs last season.
The Chargers had picked up five straight ATS losses against the Raiders until beating them 38-26 in Oakland as a 2.5-point underdog back in January. Overall San Diego is 7-3 SU and 5-5 ATS in the past 10 games between the rivals.