NFL Betting: Week 10 Opening Lines

There are three double-digit underdogs on the opening NFL betting lines for Week 10, with the Bills, Rams, and Chiefs all getting big points at the sportsbooks on the road against their opponents for this week.

The Bills opened as 12-point underdogs at 5Dimes in New England for Sunday afternoon, with Buffalo 3-5 both SU and ATS and the Patriots at 5-3 both SU and ATS on the season. New England got past Buffalo 52-28 on the road in their first meeting of the year in September.

Later on Sunday the 49ers then opened as 12.5-point favorites at 5Dimes at home against the Rams, with San Francisco 6-2 SU and 5-3 ATS and St. Louis 3-5 SU and 5-3 ATS on the season. The Rams have covered the spread in three of their past four games against the Niners.

For Monday night it's then the Steelers opening as 13-point home favorites at 5Dimes against the Chiefs, with Pittsburgh now 5-3 SU and 4-4 ATS on the year while Kansas City sits at 1-7 SU and 2-6 ATS. The Chiefs have covered the spread in each of their last two games against the Steelers.

Meanwhile, the marquee Texans vs. Bears matchup in Chicago on Sunday night opened as a pick'em at 5Dimes, with Houston 7-1 SU and 6-2 ATS on the season and Chicago boasting marks of 7-1 SU and 5-2-1 ATS. The Bears are 0-2 ATS all-time vs. the Texans.

Week 10 Opening NFL Betting Lines (from 5Dimes)

Thu - Indianapolis at Jacksonville (+3) (8:20pm ET)

Sun - NY Giants at Cincinnati (+4) (1:00pm ET)

Sun - Tennessee at Miami (-7) (1:00pm ET)

Sun - Detroit at Minnesota (+1) (1:00pm ET)

Sun - Buffalo at New England (-12) (1:00pm ET)

Sun - Atlanta at New Orleans (+1) (1:00pm ET)

Sun - San Diego at Tampa Bay (-3) (1:00pm ET)

Sun - Denver at Carolina (+4) (1:00pm ET)

Sun - Oakland at Baltimore (-9) (1:00pm ET)

Sun - NY Jets at Seattle (-7.5) (4:05pm ET)

Sun - Dallas at Philadelphia (pick) (4:25pm ET)

Sun - St. Louis at San Francisco (-12.5) (4:25pm ET)

Sun - Houston at Chicago (pick) (8:20pm ET)

Mon - Kansas City at Pittsburgh (-13) (8:30pm ET)

Week 10 NFL Betting Trends and Notes

Indianapolis at Jacksonville - Matchup Report


Indianapolis is 4-1 SU in its last 5 games

Jacksonville is 4-1 SU in its last 5 games when playing Indianapolis

Detroit at Minnesota - Matchup Report


The total has gone OVER in 12 of Detroit's last 15 games on the road

Minnesota is 13-1 SU in its last 14 games when playing at home against Detroit

Oakland at Baltimore - Matchup Report


The total has gone UNDER in 6 of Oakland's last 8 games when playing Baltimore

Baltimore is 5-0 SU in its last 5 games at home

Buffalo at New England - Matchup Report


The total has gone OVER in 4 of Buffalo's last 5 games when playing on the road against New England

The total has gone OVER in 5 of New England's last 5 games

Denver at Carolina - Matchup Report


The total has gone OVER in 6 of Denver's last 7 games on the road

The total has gone UNDER in 4 of Carolina's last 6 games

Atlanta at New Orleans - Matchup Report


Atlanta is 5-0 SU in its last 5 games

New Orleans is 6-1 SU in its last 7 games when playing Atlanta

NY Giants at Cincinnati - Matchup Report


NY Giants are 8-1 SU in their last 9 games on the road

The total has gone OVER in 5 of Cincinnati's last 6 games when playing NY Giants

San Diego at Tampa Bay - Matchup Report


The total has gone OVER in 5 of San Diego's last 5 games when playing Tampa Bay

The total has gone OVER in 5 of Tampa Bay's last 5 games

Tennessee at Miami - Matchup Report


The total has gone UNDER in 9 of Tennessee's last 10 games when playing on the road against Miami

The total has gone UNDER in 9 of Miami's last 10 games when playing at home against Tennessee

NY Jets at Seattle - Matchup Report


NY Jets are 5-1 SU in their last 6 games when playing Seattle

Seattle is 6-1 SU in its last 7 games at home

Dallas at Philadelphia - Matchup Report


The total has gone UNDER in 7 of Dallas's last 8 games on the road

The total has gone UNDER in 5 of Philadelphia's last 7 games when playing Dallas

St. Louis at San Francisco - Matchup Report


The total has gone UNDER in 8 of St. Louis's last 10 games on the road

San Francisco is 7-1 SU in its last 8 games when playing St. Louis

Houston at Chicago - Matchup Report


Houston is 7-1 SU in its last 8 games

Chicago is 5-0 SU in its last 5 games

Kansas City at Pittsburgh - Matchup Report


The total has gone OVER in 5 of Kansas City's last 6 games when playing Pittsburgh

Pittsburgh is 5-0 SU in its last 5 games at home

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