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NFL Betting: Week 16 Opening Lines

The Niners hung on for a win over the Patriots on Sunday night, and they'll now get a chance to clinch the NFC West division title this week as they play in Seattle in a game that opened as a pick'em on the NFL betting lines.

San Francisco blew a big lead against New England but came through late in the fourth quarter to earn a 41-34 win as a 3.5-point road underdog at the sportsbooks. That has the Niners at 10-3-1 SU and 9-5 ATS on the season.

The Seahawks, meanwhile, didn't have any trouble beating the Bills at the Rogers Centre in Toronto on Sunday, earning a 50-17 win as a 4.5-point favorite to sit at 9-5 SU and 10-4 ATS on the season.

San Francisco beat Seattle 13-6 as a 7.5-point home favorite back on October 18, and they'll clinch the NFC West title if they can beat the Seahawks on Sunday Night Football in a matchup that opened as a pick'em on the NFL betting lines at 5Dimes.

There were also three double-digit spreads on the opening NFL betting lines for Week 16, with New England a 15.5-point road favorite against Jacksonville, Green Bay a 13-point home favorite against Tennessee, and Denver a 14-point home favorite against Cleveland.

The Broncos ride a nine-game winning streak into their game against the Browns, which has them at 11-3 SU and 9-5 ATS on the season. Denver is also 5-0 SU and 4-1 ATS in its last five games against Cleveland dating back to 2000; the Browns are only 5-9 SU but sit at 8-5-1 ATS heading into their game this weekend.

Week 16 Opening NFL Betting Lines (from 5Dimes)

Sat - Atlanta at Detroit (+3.5) (8:30pm ET)

Sun - New Orleans at Dallas (-3) (1:00pm ET)

Sun - Tennessee at Green Bay (-13) (1:00pm ET)

Sun - Indianapolis at Kansas City (+6) (1:00pm ET)

Sun - Buffalo at Miami (-4) (1:00pm ET)

Sun - San Diego at NY Jets (-3) (1:00pm ET)

Sun - Washington at Philadelphia (+4) (1:00pm ET)

Sun - Cincinnati at Pittsburgh (-4.5) (1:00pm ET)

Sun - St. Louis at Tampa Bay (-3) (1:00pm ET)

Sun - Oakland at Carolina (-9.5) (1:00pm ET)

Sun - New England at Jacksonville (+15.5) (1:00pm ET)

Sun - Minnesota at Houston (-9.5) (1:00pm ET)

Sun - Cleveland at Denver (-14) (4:05pm ET)

Sun - Chicago at Arizona (+5) (4:25pm ET)



Sun - NY Giants at Baltimore (pick) (4:25pm ET)

Sun - San Francisco at Seattle (pick) (8:20pm ET)

Week 16 NFL Betting Trends and Notes

Atlanta at Detroit - Matchup Report


The total has gone UNDER in 5 of Atlanta's last 5 games when playing on the road against Detroit

The total has gone UNDER in 5 of Detroit's last 5 games when playing at home against Atlanta

New England at Jacksonville - Matchup Report


New England is 5-0 SU in its last 5 games when playing Jacksonville

The total has gone UNDER in 6 of Jacksonville's last 8 games at home

St. Louis at Tampa Bay - Matchup Report


The total has gone UNDER in 4 of St. Louis's last 5 games when playing on the road against Tampa Bay

Tampa Bay is 5-0 SU in its last 5 games when playing at home against St. Louis

Oakland at Carolina - Matchup Report


The total has gone UNDER in 5 of Oakland's last 5 games

The total has gone OVER in 4 of Carolina's last 6 games

Indianapolis at Kansas City - Matchup Report


Indianapolis is 10-2 SU in its last 12 games when playing Kansas City

The total has gone UNDER in 5 of Kansas City's last 6 games

San Diego at NY Jets - Matchup Report


The total has gone OVER in 5 of San Diego's last 6 games on the road

The total has gone UNDER in 5 of the NY Jets last 7 games

New Orleans at Dallas - Matchup Report


New Orleans is 6-1 SU in its last 7 games when playing Dallas

Dallas is 5-1 SU in its last 6 games

Buffalo at Miami - Matchup Report


The total has gone UNDER in 5 of Buffalo's last 6 games when playing on the road against Miami

The total has gone UNDER in 5 of Miami's last 6 games when playing at home against Buffalo

Tennessee at Green Bay - Matchup Report


The total has gone UNDER in 4 of Tennessee's last 5 games

The total has gone UNDER in 5 of Green Bay's last 5 games

Washington at Philadelphia - Matchup Report


Washington is 5-0 SU in its last 5 games

The total has gone OVER in 5 of Philadelphia's last 5 games at home

Minnesota at Houston - Matchup Report


Minnesota is 3-5-1 ATS in its last 9 games

Houston is 7-1 SU in its last 8 games

Cincinnati at Pittsburgh - Matchup Report


Cincinnati is 5-1 SU in its last 6 games

Pittsburgh is 5-0 SU in its last 5 games when playing Cincinnati

Cleveland at Denver - Matchup Report


The total has gone UNDER in 4 of Cleveland's last 5 games on the road

Denver is 5-0 SU in its last 5 games

Chicago at Arizona - Matchup Report


The total has gone OVER in 4 of Chicago's last 5 games on the road

The total has gone OVER in 4 of Arizona's last 5 games when playing at home against Chicago

NY Giants at Baltimore - Matchup Report


The total has gone UNDER in 8 of the NY Giants last 9 games on the road

Baltimore is 16-2 SU in its last 18 games at home

San Francisco at Seattle - Matchup Report


The total has gone OVER in 5 of San Francisco's last 6 games

Seattle is 5-0 SU in its last 5 games at home