NFL Odds: Week 4 Betting Trends

The defending NFC champion San Francisco 49ers have a lot of work to do after losing for the second week in a row, not to mention being dominated by an opposing defense. Two weeks ago on primetime television it was the Seattle Seahawks, and last Sunday it was the Indianapolis Colt. Week 4 kicks off Thursday night in St. Louis, where the Rams - who went 1-0-1 against the Niners in 2012 - host San Francisco.

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Dating past last season's St. Louis unbeaten exacta, the Rams are on a 5-1 ATS run against their NFC West rivals, while they come in on additional streaks of 6-1-1 as a home underdog and 7-1 in intradivision play. Conversely, the 49ers are mired in an abysmal 1-9 spread slide against NFC West foes, but have won 6 of 7 - and covered 5 - when laying -6 points or less on the road. After opening up as a 2.5-point favorite, most places have the 49ers favored by -3 points.

On Sunday, the winless New York Giants stumble into Kansas City to face the surprising undefeated Chiefs, who are laying 4.5 points. The numbers contradict how the teams have been playing, but it is what it is, as the Giants have won seven straight - and have covered six of them - against the Chiefs dating back to 1988. On the flipside, the Chiefs are nursing losing skids of 1-6 SU and 0-7 ATS when installed as the home chalk.

After playing three games over 11 days to start the season, the Philadelphia Eagles got a much-needed 12 days of rest and will travel to Denver to face Peyton Manning and the high-octane Broncos, who opened at -7.5 and are now laying -11 at most places. In the most relevant trend with these two fast-paced teams, the past four meetings have gone over the posted number dating back to 1995.

The home team has won five straight on the field in this clash, but the Eagles are in on a 7-2 ATS win streak when catching double digits since 1998. And while the Broncos are on a 7-1 ATS run against teams out of the NFC East, the Eagles are mired in a 1-7 ATS slide against AFC West teams.

49ers (-3.5) at Rams

Rams 5-1 ATS past 6 vs 49ers

49ers 6-1 SU, 5-2 ATS past 7 as road chalk of 6 or less points

Rams 6-1-1 ATS past 8 as home underdog

Rams 7-1 ATS past 8 division games

49ers 1-9 ATS past 10 division games

Ravens (-3) at Bills

OVER is 6-1 past 7 games when Bills are home dogs

Ravens 13-5 ATS in Week 4 since 1994

Bengals (-5) at Browns

Past 4 meetings here played OVER the total

Bengals 6-2-1 ATS past 9 road games

Browns won SU 3 of past 4 as home underdog

Bears at Lions

Bears 9-1 SU past 10 games vs Detroit

Seahawks (-3) at Texans

Texans 10-3 ATS past 13 as home dog since 2006

Seahawks 9-2 ATS past 11 as chalk

Colts (-9.5) at Jaguars

Colts 12-2 SU, 10-4 ATS as road favorite since 2009

UNDER is 12-1 past 13 Colts games within division

UNDER 9-3 past 12 Jaguars games within division

Giants (+3.5) at Kansas City

Giants 7-0 ATS, 6-1 SU vs Chiefs since 1988

Chiefs 0-7 ATS, 1-6 SU past 7 games as home favorite

Steelers at Vikings

Vikings OVER is 9-3 past 12 seasons before a bye week

Steelers 1-6 ATS past 7 games

Cardinals (+2.5) at Buccaneers

Cardinals lost 8 in a row SU as road underdog

Bucs 0-5 ATS past 5 years before a bye week

Jets (+4.5) at Titans

Jets 6-1 ATS past 7 vs Titans

Titans 2-7 ATS past 9 home games vs AFC East foes

Cowboys (-1) at Chargers

Cowboys last loss at SD was 1983 (3-0 SU since)

Chargers 7-2 ATS as home dog since 2004

Eagles (+11) at Broncos

Past 4 meetings since 1995 all played OVER (home team won 5 in a row SU)

Eagles 7-2 ATS as double-digit dog since 1998

Broncos 7-1 ATS past 8 vs NFC East

Eagles 1-7 ATS vs AFC West teams

Redskins at Raiders

Redskins 1-6 ATS past 7 seasons before a bye week

Patriots at Falcons

Pats won and covered three straight vs Falcons

Pats 9-3 ATS past 12 as road chalk of 1-3 points

Dolphins at Saints

Saints 14-3 ATS past 17 as home favorite

Saints just 16-17 ATS lifetime on MNF