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NFL Opening Betting Lines: Week 14

Some giant division clashes highlight the Week 14 NFL betting card.

The New Orleans Saints will look to rebound from a humiliating loss when the Carolina Panthers visit the Superdome on Sunday. The Saints, who were pummelled, 34-7, at Seattle on Monday, began the week as 3.5-point favorites over the Panthers.

The Saints have been dominant at home, going 21-8-1 against the spread in their last 30 games at the Superdome, but the Panthers seem to be immune to the Saints’ home-field advantage.

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Carolina has covered the spread in 11 of their last 12 trips to New Orleans. The Panthers have won eight straight games this season and are tied with the Saints atop the NFC South. Carolina won both meetings with the Saints last season, but New Orleans has been a different team this year with the return of coach Sean Payton.

In another huge NFC divisional clash, the Seahawks head to San Francisco with a chance to bury the 49ers in the NFC West. The 49ers have lost two straight to the Seahawks, including a 29-3 defeat at Seattle in Week 2. San Francisco trails Seattle by three games in the NFC West. A loss would eliminate the 49ers from the division race and drop them back into a muddled NFC Wild Card race. However, San Francisco seems to be finding its stride and is 7-1-1 against the spread in its last nine games.

Other notable Week 14 betting matchups . . .

Indianapolis at Cincinnati: The Bengals, who have covered the spread in all five of their home games this season, are 5.5-point favorites over the banged-up Indianapolis Colts. Both teams are in good shape in their divisions, but the winner will have a leg up on home-field advantage in the playoffs.

Detroit at Philadelphia: The Lions’ visit to Philadelphia features the highest over/under total on the board this week. The total began the week at 54, and for good reason. Detroit features one of the league’s top passing attacks, with quarterback Matthew Stafford and wideout Calvin Johnson. Philadelphia is also putting up points in bunches behind emerging star quarterback Nick Foles.