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NFL Opening Betting Lines: Week 16

Opening Week 16 NFL betting lines are up and on the move as we head into what promises to a fantastic final two weeks of the NFL season.

Meaningful games loaded with playoff implications highlight the Week 16 betting slate. In the NFC West, the Arizona Cardinals travel to the Seattle Seahawks, who can lock up the division title with a win. The Seahawks were growing favorites early in the week. After opening at -9.5, most shops had Seattle up to 10.5 early in the week. Seattle has covered the spread in 19 of its last 24 home games and is 5-2 ATS in the last seven meetings with the Cardinals. Arizona will be eliminated from the playoffs with a loss.

ADVERTISEMENT: Find all the updated NFL betting lines for Week 16 of the season at 5Dimes.

The other NFC West contender, San Francisco, hosts the Atlanta Falcons on Monday night. The 49ers opened as 10-point favorites, but the number had surged to 12.5 by Tuesday. San Francisco has won four straight and covered the spread in its last eight appearances on Monday Night Football. The Falcons are winless on the road this season and have long been playing for pride.

The Philadelphia Eagles are 3-point favorites over the Chicago Bears in another game with major playoff implications. Both teams are fighting for division titles. The line opened at Philadelphia -3.5, but the number was down to -3 almost everywhere early in the week.

The Bears are battling the Green Bay Packers and Detroit Lions in the NFC North. The Eagles are neck-and-neck with the Dallas Cowboys in the NFC East.

The Packers are hoping to get quarterback Aaron Rodgers back, when the Pittsburgh Steelers visit Lambeau Field on Sunday. Rodgers, who has been out a month since injuring his collarbone, returned to practice last week, but did not play in the Packers’ comeback win over the Cowboys. The line on the Steelers-Packers game was off the board to start the week, while bettors and books monitor Rodgers’ status.