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NFL Week 10 Odds: Mismatch Outlook

Three mismatches highlight the NFL card for Week 10, according to this week's OddsShark.com Power Rankings, including two games with more than a 20-slot difference between teams based on this week's poll.

The biggest mismatch, albeit without taking injuries into account, finds No. 2 Green Bay hosting No. 26 Philadelphia. The Packers opened as a -10-point favorite, but are now just 1-point chalk at Bovada with Green Bay quarterback Aaron Rodgers sidelined with a broken collarbone. Instead of a matchup between Rodgers and Philly's Michael Vick, it'll be Green Bay backup Seneca Wallace and surging Eagles signal-caller Nick Foles, who tied a single-game record with seven touchdown passes last week in Philadelphia's 49-20 blowout win over the Raiders.

The underlying story in this game may be Green Bay's rushing game against the Eagles' league-worst defense (419.3 yards per game). Packers rookie Eddie Lacy has a league-best 545 yards since October 1, while James Starks is the only NFL player this season with three touchdown runs of 25 yards or more.

The next big mismatch is No. 6 Indianapolis -10 at home against 27th-ranked St. Louis. Obviously another highly-anticipated quarterback matchup gone awry, as the Rams' Sam Bradford tore the ACL in his left knee in a victory at Houston. And while he's out for the season, Indy's Andrew Luck is enjoying an incredible second year. After helping the Colts produce the second-biggest turnaround in league history, this year he and the Colts are in control of the AFC South division chase.

Finally, the last mismatch to note is top-ranked Denver in San Diego, where the Broncos are laying -7.5 to the 14th-ranked Chargers. San Diego is in after a road loss to the Redskins, while Denver had last week off.

As for the consensus plays at OddsShark, the Broncos are the No. 1 choice by the pollsters, with 65 percent choosing Peyton Manning and the league's most lethal offense over the Chargers. Next up, just behind at 64 percent, are the Seahawks laying -5 down in Atlanta against the Falcons, and the Redskins (-3) at 63 percent on Thursday night in Minnesota.