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49ers double-digit chalk vs Colts

Two teams looking to bounce back from disappointing losses meet in San Francisco on Sunday, when the 49ers host the Colts.

The 49ers are big 11.5-point favorites over the visiting Colts. The 49ers were embarrassed at Seattle on Sunday night, but have had a tendency to out-perform expectations after a loss under coach Jim Harbaugh. San Francisco is 12-5 against the spread after a loss under Harbaugh.

The Colts lost at home, 24-20, to the Dolphins, and now must turn around and head to the West Coast to take on the surly 49ers. The road team has covered the spread in the past four meetings.

San Francisco is 5-3 against the spread as a double-digit favorite over the past two seasons. The Colts have not won as a double-digit dog since 2002 (Philly Nov. 10).

Totals bettors see a tempting trend at San Fran - the 49ers have played 7 straight home OVERs.

View Indianapolis Colts vs San Francisco 49ers Odds and Stats.

49ers vs Colts Betting Line: Those siding with the visitors in this matchup saw the Colts listed as 10.5-point Underdog at shops such as Bovada. Meanwhile, the over under line for the matchup was at 46 over at Sportsbook.ag.

The 49ers - Colts odds would favor the 49ers if the lines were set according to power ranks. San Francisco is rated No. 9 in our latest OddsShark poll, while the Colts sit at No. 19. Math models based on recent stats and predictive formulas point to a 20-11 win for the Colts.

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NFL WEEK 3 SPECIALS - Trent Richardson - Total Rushing Yards as a member of the Colts in the 2013 Regular Season? 
Over/Uder                      950½

NFL WEEK 3 SPECIALS - Trent Richardson - Total Touchdowns as a member of the Colts in the 2013 Regular Season?    
Over/Under                    7 - courtesy of Bovada

Indianapolis lost its last outing, a 24-20 result against the Dolphins on September 15. The Colts failed to cover in that game as a 1-point favorite, while the 44 combined points took the game OVER the total.

How They Match Up:
The game also pits San Francisco's No. 24-ranked offense, averaging 18.5 PPG, against a Colts defense that ranks No. 14 this week at 20.5 PPG. The 49ers aerial game is averaging 255.5 yards per game, more than the Colts secondary allows through the air, 249 YPG per game.

Defensively, the Colts feature the league's No. 28-rated road run defense, allowing 172 yards per game. San Francisco, meanwhile, ranks No. 15 in rushing offense at home.

A few Colts at 49ers trends to consider:
Indianapolis is 2-4 ATS in its last 6 games
Indianapolis is 10-4 SU in its last 14 games
The total has gone UNDER in 5 of Indianapolis's last 6 games
Indianapolis is 4-13 SU in its last 17 games on the road
San Francisco is 17-7-1 SU in its last 25 games
The total has gone OVER in 8 of San Francisco's last 9 games
San Francisco is 16-6-1 ATS in its last 23 games at home
San Francisco is 5-1 SU in its last 6 games at home

Next up:
Indianapolis at Jacksonville, Sunday, September 29th
San Francisco at St. Louis, Thursday, September 26th