Niners host Chargers Week 16 Odds Pick

The San Diego Chargers will be trying to keep their playoff hopes alive on Saturday night as they take on the free-falling San Francisco 49ers in NFL betting action on the road at Levi's Stadium.

The Chargers have lost two games in a row SU but remain in the AFC Wild Card picture at 8-6 SU on the season - which ranks them eighth in the AFC heading into Week 16. The Niners were eliminated from playoff contention in the NFC with their loss to the rival Seahawks in Week 15, which dropped them to just 7-7 SU and extended their losing skid to three.

San Diego Chargers vs San Francisco 49ers Sportsbook Odds and Betting Line

The San Diego Chargers betting odds line opened as 2.5-point underdogs in this one at most sportsbooks tracked here at Odds Shark (including Sportsbook), while the total was hovering around 41.5 at most shops.

Computer Prediction: San Diego Chargers vs San Francisco 49ers Pick

Handicapping models based on recent betting stats and prediction formulas pick a 19-17 win for the 49ers. View the computer score prediction and who will win the pick on the moneyline for all upcoming NFL matchups here.

San Diego Chargers vs San Francisco 49ers Odds and Stats.

Team Betting Records & Power Rankings

Betting fans of the San Francisco 49ers have seen them go 7-7 and 5-9 ATS so far this season, while the San Diego Chargers are at 8-6 and 6-8 ATS. In over under totals betting, the San Diego Chargers are 6-8, while the San Francisco 49ers are 4-10. Stay Informed: follow us on Twitter for odds specials, betting line moves and San Francisco vs San Diego injuries news.

It's a betting matchup between the No. 24-rated San Francisco 49ers and the No. 19-ranked San Diego Chargers, according to the NFL Power Rankings here at Odds Shark.

How San Diego Chargers vs San Francisco 49ers Stats Matchup

The game also pits San Francisco's No. 28-ranked offense, averaging 17.93 PPG, against a Chargers defense that ranks No. 11 this week at 21 PPG. The 49ers aerial game is averaging 198.71 yards per game, less than the Chargers secondary allows through the air, 228.14 YPG per game.

In comparing defenses, the San Diego Chargers own the league's No. 22-rated front 7 in terms of stopping the run, allowing 117.67 yards per game when on the road. San Francisco, on the other hand, rates No. 12 this week in generating rushing yards at home.

Recent Outings Betting Recap

In their last game, the Chargers were Week 15 losers coming out on the wrong end of 22-10 score against Denver.

The 49ers suffered a Week 15 loss against Seattle in their last game, falling 17-7 at CenturyLink Field.

San Diego Chargers vs San Francisco 49ers Betting Odds Trends

San Diego is 1-8 ATS in its last 9 games
The total has gone UNDER in 4 of San Diego's last 6 games
San Diego is 7-3 ATS in its last 10 games on the road
The total has gone UNDER in 6 of San Diego's last 9 games on the road
San Francisco is 1-4 ATS in its last 5 games
San Francisco is 15-8 SU in its last 23 games
The total has gone UNDER in 5 of San Francisco's last 5 games
San Francisco is 1-7 ATS in its last 8 games at home

Next Betting Matchups

San Diego at Kansas City, Sunday, December 28th
San Francisco home to Arizona, Sunday, December 28th

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