Arizona finally snapped its 11-game road losing skid last week , upsetting the Eagles and they have an even tougher task this week versus a divisional foe.

The Cardinals may have a QB controversy on their hands after John Skelton played well vs the Eagles and with Kevin Kolb returning from injury. They visit the hot San Francisco 49ers who look like Super Bowl contenders.

Arizona is a bankroll-draining 0-5 ATS past 5 vs the 49ers and they have been a solid UNDER play within the NFC West (9-2 past 11 within the division). San Francisco meanwhile is 8-0 SU and ATS 8 within the division and will be favored huge here at home.



View Arizona vs San Francisco Odds and Stats.

Betting Line:
The 49ers are listed as 10-point favorites at sportsbooks, with the total listed at 41.5.

Power Rankings / Prediction:
The game pits the 49ers, currently No. 7 in our OddsShark NFL Power Rankings, against the Cardinals, who rate No. 31 in the latest survey. Meanwhile, math and handicapping models run on this game predict a 32-18 victory for the 49ers.



How They Match Up:
Offensively, the game matches up San Francisco's No. 7-ranked offense (25.9 PPG) against a Cardinals defense that ranks No. 22 at 23.7 PPG. The 49ers passing attack has averaged 179.6 yards per game, less than the Cardinals give up through the air (255.4 YPG on average).

In comparing defenses, the Cardinals own the league's No. 27-rated front 7 in terms of stopping the run, allowing 147.8 yards per game when on the road. San Francisco, on the other hand, rates No. 13 this week in generating rushing yards at home.

Arizona won its last outing, a 21-17 result against the Eagles on November 13. The Cardinals covered in that game as a 12.5-point underdog, while the 38 combined points took the game UNDER the total. In their last game, the Cardinals got 3 passing scores out of John Skelton en route to a 21-17 win over the Eagles on Sunday at Lincoln Financial Field.

The 49ers were a 27-20 Sportsbook in their most recent outing at home against the Giants. They covered the 4–point spread as favorites, while the total score (47) made Sportsbooks of OVER bettors. In their last game, the 49ers were Week 10 Sportsbooks, coming out on top of the Giants by a score of 27-20.


Arizona Cardinals Trends:
When playing in November are 5-5
When playing on grass are 5-5
After outgaining opponent are 1-9
When playing within the division are 3-7

San Francisco 49ers Trends:
When playing in November are 6-4
When playing on grass are 8-2
After being outgained are 7-3
When playing within the division are 7-3

A few Cardinals at 49ers trends to consider:
The total has gone UNDER in 4 of Arizona's last 5 games on the road
The total has gone UNDER in 4 of Arizona's last 6 games when playing on the road against San Francisco
The total has gone UNDER in 4 of Arizona's last 6 games when playing San Francisco
Arizona is 5-11 ATS in its last 16 games on the road
San Francisco is 5-0 SU in its last 5 games
San Francisco is 6-0-1 ATS in its last 7 games at home
San Francisco is 6-1 SU in its last 7 games at home
The total has gone OVER in 6 of San Francisco's last 7 games at home


Next up:
Arizona at St. Louis, Sunday, November 27
San Francisco at Baltimore, Thursday, November 24