Bills vs. Colts: Week 12 betting

The Indianapolis Colts are 4-1 SU and ATS at home this season and will be looking for their fourth straight home win when they host the Buffalo Bills at Lucas Oil Stadium this Sunday.

Indianapolis is also 4-1 SU in its last five games overall.

The Colts are 6-1 SU and ATS past 7 home games and they are 6-1 SU vs the Bills dating back to the 1990s.

Buffalo has struggled on the road recently with a 2-11 SU and a 4-8-1 ATS record over its last 13 road games. The total has gone UNDER in four of Indianapolis's last five games and in three of Buffalo's last five games.

View Buffalo vs Indianapolis Odds and Stats.

Betting Line:
On the opening line for this matchup, the Colts sat as 3.5-point favorites at shops such as 5Dimes. The total, meanwhile, has been pegged by the oddsmakers at Bovada at 52.

Power Rankings / Prediction:
This game matches up the No. 17 (Colts) and the No. 26 (Bills) teams in the league, according to our current NFL Power Rankings at OddsShark. A 20-18 result in favor of the Colts is predicted by handicapping models.

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How They Match Up:
The game also pits Indianapolis's No. 21-ranked offense, averaging 21 PPG, against a Bills defense that ranks No. 30 this week at 29.9 PPG. The Colts aerial game is averaging 283 yards per game, more than the Bills secondary allows through the air, 234.1 YPG per game.

Defensively, the Bills feature the league's No. 30-rated road run defense, allowing 146.5 yards per game. Indianapolis, meanwhile, ranks No. 15 in rushing offense at home.

In their last action, Buffalo was a 19-14 winner at home against the Dolphins. They covered the 2.5-point spread as favorites, while the combined score (33) was profitable news for UNDER bettors. The Bills grabbed a Week 11 victory over the Dolphins in their last game, winning 19-14 at Ralph Wilson Stadium.

The Colts were a 59-24 loser in their most recent outing on the road against the Patriots. They failed to cover the 10-point spread as underdogs, while the total score (83) made winners of OVER bettors. Andrew Luck handled the Patriots defense in his team's most recent action, throwing for 334 yards and 2 scores, but Indianapolis still lost to New England 59-24.

Buffalo Bills Trends:
When playing in November are 3-7
When playing on turf are 3-7
After outgaining opponent are 4-6
When playing outside the division are 4-6

Indianapolis Colts Trends:
When playing in November are 3-7
When playing on turf are 6-4
After outgaining opponent are 4-6
When playing outside the division are 4-6

A few Bills at Colts trends to consider:
The total has gone OVER in 9 of Buffalo's last 13 games
The total has gone UNDER in 6 of Buffalo's last 9 games when playing on the road against Indianapolis
The total has gone UNDER in 6 of Buffalo's last 9 games when playing Indianapolis
The total has gone OVER in 10 of Buffalo's last 15 games on the road
Indianapolis is 6-1 SU in its last 7 games at home
The total has gone UNDER in 6 of Indianapolis's last 7 games at home
Indianapolis is 6-1 SU in its last 7 games when playing Buffalo
Indianapolis is 4-1 SU in its last 5 games

Next up:
Buffalo home to Jacksonville, Sunday, December 2
Indianapolis at Detroit, Sunday, December 2

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