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Colts hold off 49ers

Reggie Wayne caught 12 passes for 147 yards with a touchdown on Sunday, as the Indianapolis Colts defeated the San Francisco 49ers 18-14.

The Colts were a 13-point favorite in the game, but were unable to cover the spread. The combined score fell UNDER the posted over/under total (40.5).

Peyton Manning passed for 347 yards for Indianapolis and Joseph Addai rushed for 62 yards on 20 carries with a touchdown pass.

Alex Smith passed for 198 yards with a touchdown and an interception for San Francisco, while Frank Gore rushed for 91 yards and a touchdown on 13 carries.