The San Francisco 49ers are one of the few teams to have beaten the New Orleans Saints at home in recent seasons.
The 49ers went into New Orleans last year and knocked off the Saints. But that was without coach Sean Payton.
With Payton back on the sidelines, the Saints have been nearly unstoppable in the Superdome this season.
The Saints are 3-point home favorites over the 49ers. New Orleans has covered the spread in 21 of their last 26 home games and are on a 20-4 run against the spread as home chalk.