No. 2 Oregon will be looking to make a statement against an SEC opponent, when Tennessee visits Autzen Stadium.
The Ducks opened as 21-point favorites. This line is expected to climb throughout the week.
Oregon is off to its typical fast start, with blowout wins over Nicholls State and Virginia. The Ducks are 15-10-2 at home against the spread over the last five seasons.
The Volunteers are 2-0 under first-year coach Butch Jones, after easy wins over Austin Peay and Western Kentucky.
These two teams met in 2010, with the Ducks rolling to a 48-13 win in Knoxville.
Tennessee is 4-14-2 against the spread in its last 20 games as an underdog.