Week 6 NFL Picks, College Football Betting & More | Odds Shark’s Guys & Bets (Episode 281)

It’s a Football Friday! The best kind of Friday, to be honest, as Joe Osborne, Andrew Avery and Iain MacMillan give you their Week 6 NFL picks and college football best bets.

We’ll start it off with a matchup of two of the best quarterbacks of all time with Tom Brady facing Aaron Rodgers. It’s only the second time the two will go head-to-head, as odd as that sounds. Rodgers has been superb for the Green Bay Packers to start the season as he has 13 touchdown passes and zero interceptions. Brady has been what the Tampa Bay Buccaneers had expected, as he has 12 touchdown passes with only four picks. Joe is expecting fireworks in this game as he looks at the total.

Sunday Night Football features two NFC West teams as the Los Angeles Rams are in San Francisco to take on the 49ers. Last week you couldn’t have had two teams look more different as the Rams easily took care of Washington and the 49ers got whupped by the Dolphins. This could be a tough matchup for the Niners offensive line as the Rams defense is tied for the league lead in sacks with 20. Joe is eyeing the spread for his wager for this game.

For his weekly teaser bet, Joe is looking at the Miami Dolphins and Indianapolis Colts. The Dolphins face the lowly Jets at Hard Rock Stadium in Miami and are big favorites. It’s been a crazy week for the Jets: they released running back Le’Veon Bell, and Adam Gase is still their coach. The Colts are at home to Joe Burrow and the Cincinnati Bengals. The Colts are also big favorites, so getting the Dolphins and Colts inside key numbers is a big part of this teaser.

It’s an old-school rivalry in the NFC East as the New York Giants host Washington. So, this may not be one of the most exciting games on the schedule this week, but the total is an enticing bet for Ninja. Washington’s quarterback situation is a complete mess. They’ve benched Dwayne Haskins, and Kyle Allen got injured last week against the Rams, so Alex Smith had to come in and play. Yikes. Things aren’t that much better for the Giants. Daniel Jones has only thrown two touchdown passes this season but has five interceptions. New York is 31st in points scored with 81 and Washington is 29th with 89.

Ninja has the lone college football bet on the show as the 11th-ranked Texas A&M Aggies take on the Mississippi State Bulldogs. Things started off hot for the Bulldogs as they upset the defending national champion LSU Tigers on opening weekend 44-34. Since then, they’ve dropped games to Arkansas and Kentucky. A&M fell to Alabama two weeks ago but defeated the Florida Gators 41-38 in a wild game last weekend. This is a big spot for the Aggies but Ninja will break down his pick.

Iain has his sights set on the upstart Carolina Panthers as they take on the Chicago Bears. The sky certainly didn’t fall since Christian McCaffrey got injured for the Panthers. Carolina finds itself at 3-2 and in a three-way tie atop the NFC South. Iain has an excellent Teddy Bridgewater stat that backs his bet in this spot.

Finally, Underdog Iain is back! In an AFC South clash, the Houston Texans are in Tennessee to face the Titans. A nice storyline for this game is on the coaching side. Former New England Patriots linebacker Mike Vrabel goes up against his former Pats defensive coordinator Romeo Crennel. Crennel was the defensive coordinator for the Texans when Vrabel joined that franchise as the linebackers coach. As Vrabel kept moving up within the Texans organization, so did Crennel. Now we get to see them try to outdo each other on Sunday.