Boston Red Sox vs Chicago White Sox Betting Pick and Odds Preview

The Chicago White Sox host Boston on Wednesday, looking to pick up a win and improve their 24-27 mark against the 28-23 Red Sox in MLB betting odds action at Guaranteed Rate Field.

The Chicago White Sox will rely on Mike Pelfrey to turn in a quality outing on the mound in this one, while Drew Pomeranz will be his counterpart for the Boston Red Sox. Mike Pelfrey is 2-4 this season, and Drew Pomeranz is 4-3.

Sportsbook Odds & Computer Pick

Betting fans looking to pick the Chicago White Sox in this matchup found them as 133 underdogs on the MLB money line at Sportsbook. Betting the over under instead? It was 9.5 at its open earlier today and hovering near that number at Sportsbook.

Odds Shark computer score prediction models pick a possible 4.6-4.1 win for the Red Sox on Wednesday. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Boston Red Sox vs Chicago White Sox Matchup

Team Betting Records & Power Rankings

The Chicago White Sox bring a 24-27 record to the battle against the 28-23 Red Sox. Stay Informed: follow us on Twitter for odds specials, betting line moves and Chicago vs Boston injuries news.

The Chicago White Sox vs Boston Red Sox odds would favor the Red Sox if the betting lines were set according to our power ranks. Chicago is rated No. 13 in the current Odds Shark poll, while Boston is at No. 1.

Statistical Matchup

On offense, it's a battle between the Chicago White Sox and its No. 14-rated batting order, averaging 4.65 runs per nine innings, against the No. 10 line up of the Boston Red Sox at 4.86 runs per outing.

Boston brings the No. 8-rated defense to this matchup, facing the White Sox's No. 6-ranked defense.