Boston Red Sox at Cleveland Indians Betting Lines and Pick

The MLB baseball betting odds board sees a clash between Cleveland and Boston on Wednesday, with the host Indians trying to win for themselves and reward betting fans who pick them on the moneyline.

Boston puts its faith in starter Clay Buchholz to earn a win and boost his personal mark of 0-0. Getting the ball for the Cleveland Indians is Carlos Carrasco, who owns a 0-0 record on the season with a 0.00 ERA.

Sportsbook Odds & Computer Pick

Those betting on the visitors in this one found the Boston Red Sox listed as underdogs of 110 at most sportsbooks, including Sportsbook. Total bettors saw the number open in the area of 7, check for odds updates at Sportsbook.

Handicapping models based on recent betting stats and prediction formulas pick a 5.6-2.4 win for the Indians. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Boston Red Sox vs Cleveland Indians Matchup

Team Betting Records & Power Rankings

The Cleveland Indians sport a record of 0-1 heading into this matchup, while the Boston Red Sox sit at 1-0 on the season Stay Informed: follow us on Twitter for odds specials, betting line moves and Cleveland vs Boston injuries news.

This game puts the Cleveland Indians, most recently No. 4 in Odds Shark MLB Power Rankings, up against the Boston Red Sox, who rate a No. 7 in the latest survey.

Statistical Matchup

When it comes to getting on base, the visiting Boston Red Sox rank No. 5 at 11 hits per game. That compares with the Cleveland Indians No. 25 ranking in that category.

Pitching and defensive stats are important baseball handicapping betting factors and Cleveland has the No. 21-ranked defense. In the other dugout, the Red Sox own the No. 6 mark in runs allowed.