Flag Our Top Sportsbooks
50% BONUS Up To $1000
50% BONUS Up To $1000
125% BONUS Up To $2500
The Chicago White Sox take on the San Francisco Giants on Friday night.

The Chicago White Sox (35-39) are 8-2 SU in their 10 games against the San Francisco Giants (40-34) since 2008. The White Sox will be looking for more success against the Giants as a White Sox vs Giants prediction underdog this Friday night in San Francisco.

Join A Top-Tier MLB Betting Site Now

White Sox vs Giants Betting Preview

White Sox vs Giants Odds & Analysis

Opening Odds

The Giants opened as -147 favorites and have settled in at San Francisco -147 while the White Sox are listed as +126 road underdogs. The UNDER has been a popular White Sox vs Giants prediction in this interleague matchup, moving the line down to 7.5 runs after it opened at eight runs. Six of the last eight games between San Francisco and Chicago have gone OVER the posted total.

Starting Pitchers

Lance Lynn's struggles continued last Saturday as the veteran right-hander pitched 6.2 innings and allowed five earned runs in a 6-2 White Sox loss to the Baltimore Orioles. Lynn has made three starts this season since returning from the injured list in June and has recorded a 6.19 ERA and a 1.44 WHIP in those three starts.

Alex Cobb pitched 4.1 innings and surrendered five hits and two earned runs in San Francisco's 4-2 loss to the Cincinnati Reds last Friday. Cobb is off to a rough start in his first season with the Giants, compiling a 5.48 ERA and a 1.46 WHIP across 10 starts in 2022.

Get the best White Sox vs Giants odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
  • Best Moneyline
  • Best Total

Chicago And Its Bats Are Back In Another Slump

The White Sox had a rare outburst on offense in an 11-4 win over the Los Angeles Angels on Tuesday, but they followed that effort up with a 4-1 loss on Wednesday to fall to 2-6 SU over their last eight games. Even with that 11-run game included, Chicago has averaged only 3.38 runs per game over this current eight-game slump.

Chicago went 6-2 SU and averaged 6.88 runs per game in the eight games prior to this recent slump. Bettors taking Chicago as their White Sox vs Giants prediction will be looking for that version of the White Sox to show up against San Francisco on Friday.

San Francisco Has Been Streaky In 2022

The Giants fell to 3-7 SU over their last 10 games with a 3-2 loss to the Detroit Tigers on Wednesday night. San Francisco closed as a -200 favorite in that game and has lost as a favorite of -160 or higher four times during this recent slump.

Big ups and downs have been common for the Giants this season. San Francisco went 7-1 SU in the eight games before this recent slump and has had four different winning streaks of five games or more in 2022. But the club has also had two five-game losing streaks this year and is certainly in bad form at the moment after going 2-3 SU at home in its last five games against the lowly Tigers and Cincinnati Reds.

White Sox vs Giants Pick & Insights

White Sox: Keys to Victory

Chicago is 8-1 SU in its last nine games with four or more runs scored and 0-8 SU in its last eight games when scoring three runs or less. With Lance Lynn still finding his form after a long stint on the injured list, the White Sox need to have a good day at the plate if they hope to pull off an upset as a White Sox vs Giants prediction.

Giants: Keys to Victory

Alex Cobb is 1-3 with an 8.34 ERA and a 1.90 WHIP in five career starts against the White Sox. The Giants should be able to produce on offense against Lynn and this shaky White Sox bullpen, but they'll need Cobb to pitch well enough to keep this one close to give them a shot at being the winning White Sox vs Giants pick.

MLB Computer Pick: White Sox +126 ML 

Check out more of our signature MLB computer picks, plus our favorite sportsbooks that serve baseball customers.

Shark Bites
  • Chicago is 4-1 SU in its last 5 road games vs San Francisco.
  • San Francisco is 2-5 SU over its last 7 games.
  • The UNDER is 6-1 in Chicago's last 7 games.