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The St. Louis Cardinals take on the Chicago Cubs on Friday night.

The St. Louis Cardinals (40-32) are 10-4 SU in their last 14 games against the Chicago Cubs (26-44). The Cardinals will try to keep things rolling against their NL Central rivals in the first game of this three-game series as a Cubs vs Cardinals prediction winner Friday night in St. Louis. 

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Cubs vs Cardinals Odds & Analysis

Opening Odds

The Cardinals opened as -161 favorites and have settled in at St. Louis -160 in this division rivalry game against the Cubs, who are listed as +135 underdogs. The OVER has been the preferred Cubs vs Cardinals prediction and bet on the total in this matchup, bumping the line up to nine runs after it opened at 8.5 runs. Five of St. Louis’s last six home games have gone OVER the posted total.

Starting Pitchers

Kyle Hendricks was lit up for eight hits and six earned runs in 4.1 innings pitched last Sunday in a 6-0 Cubs loss to the Atlanta Braves. Hendricks had the worst season of his career last year with a 4.77 ERA and a 1.35 WHIP, and he’s off to an even worse start in 2022 with a 2-6 record, a 5.43 ERA and a 1.35 WHIP through 13 starts.

Andre Pallante is set to make his fourth start of the season on Friday night against the Cubs. Pallante has recorded a 2-2 record with a 1.69 ERA and a 1.34 WHIP in 42.2 innings pitched across his three starts and 18 bullpen appearances.

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Chicago Hasn’t Won A Road Series In Over A Month

The Cubs snapped a seven-game road losing streak on Wednesday night with a 14-5 win over the Pittsburgh Pirates, but they went on to drop the series two games to one with an 8-7 loss on Thursday night. Chicago is now 1-8 SU over its last nine road games and 13-19 SU on the road this season.

Since winning four games in a five-game stretch back at the beginning of June, the Cubs have gone just 3-14 SU over their last 17 games. Bettors taking Chicago as their Cubs vs Cardinals prediction will be hoping for another effort like the team had in its blowout win over the Pirates on Wednesday.

St. Louis Hopes To Remain Hot At Home In This Series

The Cardinals wrapped up a seven-game road trip with a 6-4 loss to the Milwaukee Brewers on Wednesday night. St. Louis split the four-game series against Milwaukee with two games apiece, but settled for a 3-4 SU record on the trip after losing two of three to the Red Sox in Boston.

Now the Cardinals return home, where they are 10-3 SU over their last 13 home games. St. Louis has been considerably better at home this season with a 21-13 SU record than it has been on the road with a 19-19 SU record. 

Cubs vs Cardinals Pick & Insights

Cubs: Keys to Victory

After scoring only two total runs in their previous three games, the Cubs have racked up 21 runs over their last two games. If Chicago can continue to hit well up and down the lineup on Friday, the club will have a shot at pulling off an upset as a Cubs vs Cardinals prediction.

Cardinals: Keys to Victory

The Cubs have gone 1-4 SU in Kyle Hendricks’ last five starts with Hendricks recording an 8.10 ERA over that stretch. St. Louis shouldn’t have too much trouble producing runs against Hendricks and this shaky bullpen, so even just a decent start from Andre Pallante should be enough to lead St. Louis to a win as a Cubs vs Cardinals pick.

MLB Computer Pick: Cubs +145 ML

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Shark Bites
  • Chicago is 18-30 SU as an underdog this season.
  • St. Louis is 9-4 SU in its last 13 games vs NL teams.
  • The OVER is 9-3-1 in St. Louis’s last 13 games.