MLB Odds with Pick - Chicago White Sox vs Chicago Cubs

The MLB baseball betting odds board sees a clash between Chicago and Chicago on Friday, with the host Cubs trying to win for themselves and reward betting fans who pick them on the moneyline.

Chicago puts its faith in starter Carson Fulmer to earn a win and boost his personal mark of 2-2. Getting the ball for the Chicago Cubs is Tyler Chatwood, who owns a 2-3 record on the season with a 3.31 ERA.

Handicapping models based on recent betting stats and prediction formulas pick a 5.4-5.0 win for the White Sox. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Chicago White Sox vs Chicago Cubs Matchup

Team Betting Records & Power Rankings

Chicago (19-15) will face the 9-25 White Sox in this tilt. Stay Informed: follow us on Twitter for odds specials, betting line moves and Chicago vs Chicago injuries news.

The Odds Shark MLB Power Rankings have the Chicago Cubs at No. 5 and the Chicago White Sox at No. 28 heading into this contest.

Statistical Matchup

On offense, it's a battle between the Chicago Cubs and its No. 4-rated batting order, averaging 5.24 runs per nine innings, against the No. 23 line up of the Chicago White Sox at 4 runs per outing.

Pitching and defensive stats are important baseball handicapping betting factors and Chicago has the No. 8-ranked defense. In the other dugout, the White Sox own the No. 29 mark in runs allowed.

Recent Outings Betting Recap

Chicago suffered a 6-5 loss against Pittsburgh on Wednesday, as Reynaldo Lopez wasn't able to lead his team to victory at Guaranteed Rate Field.

Chicago looks to continue its winning ways following a victory last time out against the Marlins, a 13-4 final on Wednesday in support of J Quintana at Wrigley Field.

Betting Trends