Cleveland Indians Home to the Chicago White Sox in MLB Betting Odds Action

The Cleveland Indians will look to improve on a 28-25 record when they take on the Chicago White Sox, a key part of the MLB betting odds line up on Wednesday.

The Cleveland Indians will rely on Corey Kluber to turn in a quality outing on the mound in this one, while Reynaldo Lopez will be his counterpart for the Chicago White Sox. Corey Kluber is 7-2 this season, and Reynaldo Lopez is 1-3.

Sportsbook Odds & Computer Pick

Those betting on the visitors in this one found the Chicago White Sox listed as underdogs of 255 at most sportsbooks, including Sportsbook. Total bettors saw the number open in the area of 8, check for odds updates at Sportsbook.

Odds Shark computer prediction handicapping models run on this game pick a 5.2-3.8 victory for the Indians. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

Chicago White Sox vs Cleveland Indians Matchup

Team Betting Records & Power Rankings

Cleveland (28-25) will face the 16-36 White Sox in this tilt. Stay Informed: follow us on Twitter for odds specials, betting line moves and Cleveland vs Chicago injuries news.

It's a MLB baseball betting matchup between the No. 6-rated Cleveland Indians and the league No. 26-ranked Chicago White Sox, according to the latest MLB power poll here at Odds Shark.

Statistical Matchup

Rating these teams in several key categories is important for handicappers and Cleveland has baseball's No. 6-rated offensive output, at 8.89 hits per game. The Chicago White Sox average 8.4 hits per game, good for No. 14 on the list.

Comparing defensive stats, Chicago owns the No. 28-rated road mark, allowing 5.69 runs per game on the highway. Cleveland, on the other hand, rates No. 2 in scoring at home.