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BoSox host the Yankees at Fenway Park

John Lackey is expected to get the ball for the Boston Red Sox on Wednesday night as they take on the rival New York Yankees in marquee MLB betting action at Fenway Park.

Lackey is 2-2 with a 5.25 ERA on the season, and he gave up six runs over 5 2-3 innings of work when he last faced the Yankees back on April 12. Overall the righthander is 10-11 with a 4.99 ERA over his 28 career starts against New York. Michael Pineda (2-1 so far this season) will take the mound for New York Yankees.

New York Yankees vs Boston Red Sox Opening Odds and Betting Line

The New York Yankees were listed as 108 underdogs on the MLB baseball moneyline at many online sportsbooks, including 5Dimes. The total was set at 8.5 before betting started earlier on Wednesday over at Bovada.

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Computer Prediction: New York Yankees vs Boston Red Sox Pick

Odds Shark prediction models pick the Yankees to win this game 4-3.6. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

New York Yankees vs Boston Red Sox Odds and Stats.

Team Betting Records & Power Rankings

The Boston Red Sox sport a record of 9-12 heading into this matchup, while the New York Yankees sit at 12-8 on the season Stay Informed: follow us on Twitter for odds specials, betting line moves and Boston vs New York injuries news.

This game matches up the No. 21 (Boston Red Sox) and the No. 19 (New York Yankees) teams, according to our current MLB Power Rankings.

How New York Yankees vs Boston Red Sox Stats Matchup

Rating these teams in several key categories is important for handicappers and Boston has baseball's No. 24-rated offensive output, at 8.19 hits per game. The New York Yankees average 9.4 hits per game, good for No. 3 on the list.

New York brings the No. 19-rated defense to this matchup, facing the Red Sox's No. 17-ranked defense.

Recent Outings Betting Recap

New York won its last outing, a 9-3 result against the Red Sox on April 22. Bettors who backed the Yankees at +110 on the moneyline won on the day, and the total score (12) sent OVER bettors to the payout window. New York got the job done in their last match in a 9-3 victory over Boston on Tuesday at Fenway Park behind starter Masahiro Tanaka.

Next Betting Matchups

New York at Boston, Thursday, April 24th