MLB Odds with Pick - New York Yankees vs Chicago White Sox

The Chicago White Sox will try to be nasty hosts on Tuesday when the New York Yankees pay a visit to Guaranteed Rate Field.

Luis Severino gets the ball in front of a hostile crowd for the New York Yankees on Tuesday; he's 5-3 on the season. The Chicago White Sox, meanwhile, will counter with Jose Quintana, who will be looking to improve on his 4-8 mark.

Sportsbook Odds & Computer Pick

Baseball betting odds makers, including Sportsbook, opened the Chicago White Sox as 122 moneyline underdogs in this matchup. Over under total bettors saw the number open at 8.5 at shops such as Sportsbook.

Handicapping models based on recent betting stats and prediction formulas pick a 5.0-3.4 win for the Yankees. View the computer score prediction and who will win the pick on the moneyline for all upcoming MLB matchups here.

New York Yankees vs Chicago White Sox Matchup

Team Betting Records & Power Rankings

The Chicago White Sox bring a 32-43 record to the battle against the 41-33 Yankees. Stay Informed: follow us on Twitter for odds specials, betting line moves and Chicago vs New York injuries news.

This game puts the Chicago White Sox, most recently No. 21 in Odds Shark MLB Power Rankings, up against the New York Yankees, who rate a No. 5 in the latest survey.

Statistical Matchup

Scoring stats point to some edges in this matchup. The game features the Chicago White Sox No. 21-ranked scoring average of 4.56 runs per game, against a New York Yankees offense rated No. 2 and scoring 5.59 runs per game. The White Sox have averaged 9.01 hits per game to date this season, less than the Yankees hitters have managed (9.47 per nine innings).

Pitching and defensive stats are important baseball handicapping betting factors and Chicago has the No. 14-ranked defense. In the other dugout, the Yankees own the No. 7 mark in runs allowed.