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Padres vs Diamondbacks Prediction & Betting

The San Diego Padres (0-1) are 1-9 over their last 10 road games, including their season-opening loss to the Arizona Diamondbacks (1-0) on Thursday night. The Padres will try to turn things around with a road victory as a Padres vs Diamondbacks prediction Friday night in Arizona.

Padres vs Diamondbacks Betting Preview

Padres vs Diamondbacks Odds & Analysis

Opening Odds

The Padres opened as -155 favorites before action on Arizona as a popular Padres vs Diamondbacks prediction drove the line down to San Diego -132. Arizona is going off as a +122 home underdog and the total in this NL West matchup is set at 9 runs. The UNDER is 9-4 in San Diego’s last 13 games played in April.

Get the best Padres vs Diamondbacks odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    +115
    -130
    SD-1.5
    +1.5ARI
  • Best Moneyline
    -131
    +126
    SD
    ARI
  • Best Total
    +101
    -115
    Over9
    9Under

Starting Pitchers

San Diego took advantage of the Oakland Athletics’ offseason fire sale to trade for veteran left-hander Sean Manaea. Manaea posted a 3.91 ERA and a 1.23 WHIP with 194 strikeouts in 179.1 innings pitched with the A’s last season and should fit right in as a quality starter in San Diego.

Merrill Kelly posted a 4.44 ERA and a 1.29 WHIP last season across 27 starts. He did pitch well in three starts against the Padres, though, with a 2.25 ERA and a 1.19 WHIP to lead the Diamondbacks to a 2-1 record against San Diego in those three games.

San Diego Must Find Ways To Win Without Fernando Tatis Jr.

The Padres appeared to be on their way to a 2-0 win on Thursday night before Robert Suarez and Craig Stammen combined to give up four runs without recording an out in the bottom of the ninth inning. And so San Diego opened its season with a loss, an all-too-familiar result after last season’s 12-34 collapse down the stretch.

With Fernando Tatis Jr. expected to miss up to three months of the season due to a wrist injury, San Diego is going to need to figure out a way to stay in contention without its best player.

Bettors taking San Diego as their Padres vs Diamondbacks prediction will be looking for a much better performance on offense than the Padres produced on Thursday.

Arizona Has Enjoyed Success At Home Vs San Diego

Seth Beer’s three-run walk-off home run gave the Diamondbacks and their fans a highlight-reel moment right out of the gate. Exciting moments like that one were few and far between in 2021 when Arizona tied the Baltimore Orioles for MLB’s worst record of 52-110.

The win continued a trend in recent years of Arizona having success against San Diego at home. The Diamondbacks are 16-4 in their last 20 games at home against the Padres, including a 5-1 win with Merrill Kelly on the mound last April.

Padres vs Diamondbacks Pick & Insights

Padres: Keys To Victory

The Padres have the better lineup on paper and are sending the better starting pitcher to the mound in Sean Manaea. With all due respect to the Diamondbacks, the Padres really just need to stop beating themselves if they want to be the winning Padres vs Diamondbacks pick on Friday night.

Diamondbacks: Keys To Victory

All of the pressure is on the Padres in this series. The rebuilding Diamondbacks are playing with house money after winning the series opener, and that lack of pressure could lead to another upset as a Padres vs Diamondbacks prediction in this one.

Odds Shark’s Computer Padres vs Diamondbacks Prediction: Padres -132

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Shark Bites
  • San Diego is 1-9 in its last 10 games.
  • Arizona is 5-11 in its last 16 home games.
  • The OVER is 3-1-1 in Arizona’s last 5 games.
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