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The Dodgers take on the Padres on Friday night.

The Los Angeles Dodgers (72-33) are 14-2 in their last 16 games against the San Diego Padres (61-47). The Dodgers will try to keep things rolling against the Padres with a win as a Padres vs Dodgers prediction favorite in Friday night’s series opener in Hollywood.

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Padres vs Dodgers Betting Preview

Padres vs Dodgers Odds & Analysis

Opening Odds

The Padres vs Dodgers predictions and bets on both sides of this NL West rivalry matchup have been fairly even on both sides as the betting line hasn’t changed since opening at Los Angeles -151. San Diego is going off at +139 on the road and the total is set at 8.5 runs. The UNDER is 5-2 in the last seven games between the Dodgers and Padres.

Get the best Padres vs Dodgers odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -140
    +125
    SD+1.5
    -1.5LA
  • Best Moneyline
    +154
    -160
    SD
    LA
  • Best Total
    -115
    +110
    Over8.5
    8.5Under

Starting Pitchers

Sean Manaea bounced back from a rough start in his previous outing to allow only two runs in six innings pitched last Sunday night in San Diego’s 3-2 win over the Minnesota Twins. Manaea has struggled in his first season in San Diego with a 4.25 ERA and a 1.27 WHIP through 19 starts.

Tony Gonsolin pitched five innings and allowed three earned runs in a 7-3 Dodgers win over the Colorado Rockies last Sunday. Gonsolin has recorded a 6.75 ERA over his last three starts, but he still carries an impressive 12-1 record, 2.41 ERA and 0.90 WHIP into Friday night’s trip to the hill.

Juan Soto And Josh Bell Have Hit The Ground Running In San Diego

Juan Soto hit a double and a triple in San Diego’s 7-3 loss to the Rockies on Thursday night. Josh Bell also recorded two hits with a run and an RBI in the loss. Soto was understandably the player to grab all of the headlines in the Padres’ monster deal with Washington as a generational talent who is just 23, but the addition of Bell shouldn’t be overlooked as he is batting .303 with 58 RBIs this season.

A lineup featuring Soto, Bell and Manny Machado is fearsome enough, and it’s about to get even better when Fernando Tatis Jr. makes his long-awaited return this month. San Diego is 5-1 over its last six games and looks primed for success down the stretch.

Los Angeles Has Settled In To A Dominant Run

The Dodgers wrapped up their most recent eight-game road trip with a 7-1 record, winning the last five games of the trip, including a four-game sweep of the San Francisco Giants this week. Los Angeles is now 27-5 over its last 32 games and an MLB-best 72-33 on the season.

It will be interesting to see how the red-hot Dodgers fare against the newly improved Padres this weekend. Bettors taking Los Angeles as their Padres vs Dodgers prediction on Friday believe that this squad is up to the task.

Padres vs Dodgers Pick & Insights

Padres: Keys To Victory

Juan Soto went 2-for-4 with two RBIs in the Washington Nationals’ 4-1 win over the Dodgers with Tony Gonsolin on the mound last month. Another big game from Soto on Friday could prolong Gonsolin’s recent struggles and help San Diego earn a win as a Padres vs Dodgers prediction.

Dodgers: Keys To Victory

The Dodgers have outscored their opponents 60-23 over their current 8-1 run. Los Angeles is in the zone both at the plate and on the mound, and if that continues Friday, the club has an excellent chance at cashing in as a Padres vs Dodgers pick at home.

MLB Computer Pick: Dodgers -160 ML

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Shark Bites
  • San Diego is 6-13 in its last 19 road games.
  • Los Angeles is 5-0 over its last 5 games.
  • The OVER is 8-3-1 in San Diego’s last 12 games.